Dr. Inigo San Millan
Human metabolism is still widely misunderstood. After 30 years working across elite sport, metabolic health and disease, I share insights on metabolism, mitochondrial function, physiology and how they connect performance and health.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 12 | Founded | 4 months ago | Last Issue | 18 days ago |
| Active | |||||
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inigosanmillan.substack.comLatest Issues
Could Cancer Cachexia Begin as a Glucose Crisis?
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Cancer cachexia is one of the most devastating syndromes in medicine and one of the most therapeutically resistant despite decades and billions of dollars in research targeting what has been considered its primary cause.
It...
Let Me Tell You About the mLOC
Most people interested in exercise physiology have heard of mitochondria. Many have also heard of lactate. Yet very few people have heard of the molecular machinery that connects the two. That machinery is known as the mitochondrial lactate...
Mitochondria Produce Lactate? Not So Fast.
A recent paper published in Cell Metabolism (DOI: 10.1016/j.cmet.2026.02.020) has generated considerable excitement by proposing that mitochondria may produce lactate as part of a mechanism termed “lactate-carried mitochondrial energy overf...
The New Metabolic Map Part II: How It Aligns with Classical Thresholds and Exercise Domains
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After publishing the previous article on metabolic equilibrium and the four metabolic states, the most common and most thoughtful question I received was this: how does this framework relate to the models we already use? Wher...
Alzheimer´s Disease: The Diabetes of the Brain?
I have spent my career studying how cells produce and consume energy. Muscle cells, cancer cells, mitochondrial dysfunction cells… The question is always the same: what is the fuel, where does it come from and what happens when the system b...
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Human metabolism is still widely misunderstood. After 30 years working across elite sport, metabolic health and disease, I share insights on metabolism, mitochondrial function, physiology and how they connect performance and health.
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