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NewLimit Blog

Brian Armstrong, Jacob C. Kimmel, Blake Byers, Cathy O'Hare

Progress reports from our work to develop epigenetic reprogramming medicines for aging

Platform
Substack
PricingOnly free issuesPublishesMonthly
Issues36SubscribersRead blog.newlimit.com

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Latest Issues

Recent posts by this newsletter. Browse the email archive.

2025 Year in Review

We founded NewLimit in 2022 to develop reprogramming medicines that add happy, healthy years to people’s lives. We imagined it would take five years or more before our fundamental science was mature enough to start developing medicines.

2 months ago
19
0

September // October 2025 Progress Update

We are close to holding our first clinic-bound reprogramming medicine in hand. Scientists across each of our teams have spent the past several months building the final version of a therapeutic payload that restores youthful function in hep...

3 months ago
21
0

NewLimit has raised an additional $45M from Lilly, Duke University, Section 32, & Abstract on a $1.62B cap

Five months after closing our Series B, NewLimit has raised an additional $45M from Eli Lilly and Company, Duke Management Co, Section 32, and others on a $1.62B cap. Insiders including Kleiner Perkins, Dimension, Abstract, Human Capital, a...

4 months ago
17
0

July // August 2025 Progress Update

We’ve spent the latter months of summer moving our most advanced prototype medicines from discovery toward development. Our most recent data have convinced us that we’re on track to launch a human trial in the coming years, and these are th...

5 months ago
6
0

Authors

The writers behind this newsletter.

  • Brian Armstrong

    Co-founder and CEO at Coinbase

  • Jacob C. Kimmel

    Co-founder & President @ NewLimit

  • Blake Byers

    building and investing in tech + biotech companies // prev partner @GVteam, @Stanford PhD

  • Cathy O'Hare

    Scientist by training; generalist by nature. Head of Ops at NewLimit.

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