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Califf's Commentary

Rob Califf

Practiced intensive care cardiology, outpatient cardiology and did clinical research for > 30 years. Founded the Duke Clinical Research Institute. Served as 23rd and 26th FDA Commissioner. Worked at Alphabet from 2017-22.

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Latest Issues

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Image credit: Pauline Wee & DAIR / https://betterimagesofai.org / https://creativecommons.org/licenses/by/4.0/

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Finding Our Mission in the Midst of Transformative Change

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The Much-Feared FDA Form 483, Part 3

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This is the third in a three-part series on the FDA’s Form 483, a tool that the agency uses to notify firms that an investigator has found evidence for lack of adherence to quality regulations related to the manufactu...

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The Much-Feared FDA Form 483, Part 2

Adrien/Unsplash

In Part 1 of this series on the FDA’s use of a regulatory instrument known as Form 483, I put forward my view of the form and how I hope it will be used to improve quality across the board rather than as a single summary es...

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The Much-Feared FDA Form 483

US Food and Drug Administration

In this first of three related posts, I’ll be diving into a topic that some may find esoteric, but which I believe it has a significant effect on the efficiency and effectiveness of manufacturing and clinica...

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  • Rob Califf

    Practiced intensive care cardiology, outpatient cardiology and did clinical research for > 30 years. Founded the Duke Clinical Research Institute. Served as 23rd and 26th FDA Commissioner. Worked at Alphabet from 2017-22.

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