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The Dependent Variable

Rebuilding cardiovascular physiology from first principles.

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PricingOnly free issuesPublishesTwice weekly
Issues11Founded2 months agoLast Issue5 days ago
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Latest Issues

Episode VI: The Bathtub Menace

It is a period of hydraulic confusion. The venous reservoir appears to supply the force returning blood to the heart, while the cardiac pump merely restores what has been lost. But an old law of physics has been disturbed. A reservoir that...

5 days ago
3

Episode V: The Reservoir Awakens

It is a time of uneasy equilibrium. The phantom pressure has been challenged, but not defeated. A fixed volume of blood still stretches compliant vessels, storing energy and limiting the circulation’s possible states. Now a new defender has...

12 days ago
4

Episode IV: The Phantom Pressure

The gradient has survived the rebellion. Mean systemic pressure still appears to sit upstream of the right atrium, driving blood home. But as George Brengelmann opens the black box, a troubling question emerges: where, in the flowing circul...

21 days ago
2
2

Episode III: Return of the Elastic State

It is a period of haemodynamic uncertainty. The gradient has been challenged, the numerator has struck back, and the old equation can no longer explain itself. From the compliant depths of the venous circulation, a forgotten state is about...

25 days ago
8
2

Episode II: The Numerator Strikes Back

A new gradient had entered the circulation…

In 1955, Arthur Guyton changed the way physiologists thought about cardiovascular function. The circulation was no longer viewed simply as a heart pumping into a passive network of vessels, but a...

a month ago
11

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