The Dependent Variable
Rebuilding cardiovascular physiology from first principles.
| Platform |  | Pricing | Only free issues | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 8 | Founded | 2 months ago | Last Issue | 4 days ago |
| Active | |||||
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Episode III: Return of the Elastic State
It is a period of haemodynamic uncertainty. The gradient has been challenged, the numerator has struck back, and the old equation can no longer explain itself. From the compliant depths of the venous circulation, a forgotten state is about...
Episode II: The Numerator Strikes Back
A new gradient had entered the circulation…
In 1955, Arthur Guyton changed the way physiologists thought about cardiovascular function. The circulation was no longer viewed simply as a heart pumping into a passive network of vessels, but a...
Episode I: A New Gradient
A long time ago, in a laboratory far, far away, a new way of seeing the circulation was born…
Some papers change what we know. A few change how we think.
Arthur Guyton’s 1955 papers did something rarer still: they gave cardiovascular phys...
The Capacitance Problem
I’m increasingly convinced we should stop using the term “vascular capacitance” in haemodynamics.
Not because the circulation cannot accommodate volume. It clearly can.
The problem is that “capacitance” is used a lot while meaning differe...
Venous Congestion Is Not Back-Pressure
I used to teach that venous congestion reduced organ blood flow because it reduced the pressure gradient across the capillary bed.
The explanation seemed obvious. Blood enters an organ from the arterial side and leaves through the venous s...
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Rebuilding cardiovascular physiology from first principles.
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