The Dependent Variable
Rebuilding cardiovascular physiology from first principles.
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 20 | Founded | 4 months ago | Last Issue | 9 days ago |
| Active | |||||
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thedependentvariable.comLatest Issues
Acid–base, Part 3: A question of interpretation
Someone hands you a blood gas. The standard base excess is −8.
What caused it?
Part 1 took us through H⁺, buffers and the first reading of a blood gas. Part 2 went deeper into the chemistry and explored how the composition of plasma chang...
Acid–base, Part 2: A question of independence
Stewart, bicarbonate and who’s actually in charge.
In Part 1, we followed molecules picking up and releasing H⁺. We saw how those exchanges settle at a balance, how the tiny amount of H⁺ left free gives us the pH, and how Henderson–Hasselb...
Acid–base, Part 1: A question of balance
When I was a brand-new ICU trainee, around 20 years ago, I was given a photocopied article about Stewart’s approach to acid–base physiology.
It was a long article. I understood some of it, recognised that there was something important in t...
The Afterload Problem
Afterload is usually taught as “the load the heart pumps against.”
It sounds straightforward until you ask what that load actually is.
Arterial pressure? Systemic vascular resistance? Aortic impedance? Effective arterial elastance? Ventri...
The Pressure That Wasn’t Measured
A brief extra post outside my usual schedule. I came across this paper while reviewing the recent haemodynamics literature and thought it was too relevant to leave until later. It connects directly with two themes I’ve been exploring here...
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Rebuilding cardiovascular physiology from first principles.
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