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The Infinitesimal

Sasha Gusev

Thinking about genetics in a world where every variant is causal but only a tiny bit.

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Latest Issues

Embryo selection company Herasight goes all in on eugenics

Anselm Kiefer, Die Ungeborenen (The Unborn), 2002

Update: Jonathan Anomaly, director of scientific research and communication for Herasight and whose articles I criticize here, responds in a detailed comment. I recommend reading his respon...

6 months ago
85
96

More missing heritability discourse

Untitled (from “On a Clear Day”), Agnes Martin, 1973

There has been a flurry of discussion on missing heritability over the past few weeks, so I want to highlight a few articles worth reading for different perspectives on the topic. I have...

6 months ago
78
28

The missing heritability question is now (mostly) answered

Untitled (from “On a Clear Day”), Agnes Martin, 1973

The “missing heritability” conundrum goes like this: (1) twin studies, which contrast phenotypic correlations between monozygotic and dizygotic twins, tend to estimate the heritability o...

7 months ago
162
81

Beneath the surface of the sum

Interaction, Julian Stanczak, 1964

Biology is full of interactions: genes regulate other genes, proteins form into complexes, cells exchange signals through receptors, tissues coordinate their function through hormones, and so on. And yet...

9 months ago
35
5

What we talk about when we talk about risk

Ellsworth Kelly, Black Curve, 1972

Polygenic risk prediction is becoming commonplace, raising the question of what exactly “risk” means. Nowhere is this question thornier than in the application to polygenic embryo selection1, where compan...

10 months ago
83
13

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  • Sasha Gusev

    Statistical geneticist. Associate Professor of Medicine at Dana-Farber Cancer Institute / Harvard Medical School

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