
Thinking about genetics in a world where every variant is causal but only a tiny bit.
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Anselm Kiefer, Die Ungeborenen (The Unborn), 2002
Update: Jonathan Anomaly, director of scientific research and communication for Herasight and whose articles I criticize here, responds in a detailed comment. I recommend reading his respon...
Untitled (from “On a Clear Day”), Agnes Martin, 1973
There has been a flurry of discussion on missing heritability over the past few weeks, so I want to highlight a few articles worth reading for different perspectives on the topic. I have...
Untitled (from “On a Clear Day”), Agnes Martin, 1973
The “missing heritability” conundrum goes like this: (1) twin studies, which contrast phenotypic correlations between monozygotic and dizygotic twins, tend to estimate the heritability o...
Interaction, Julian Stanczak, 1964
Biology is full of interactions: genes regulate other genes, proteins form into complexes, cells exchange signals through receptors, tissues coordinate their function through hormones, and so on. And yet...
Ellsworth Kelly, Black Curve, 1972
Polygenic risk prediction is becoming commonplace, raising the question of what exactly “risk” means. Nowhere is this question thornier than in the application to polygenic embryo selection1, where compan...
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The writers behind this newsletter.
Statistical geneticist. Associate Professor of Medicine at Dana-Farber Cancer Institute / Harvard Medical School
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