Alexey’s Substack
Alexey TolchinskyMy personal Substack
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 14 | Founded | a year ago | Last Issue | 10 days ago |
| Active | |||||
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alexeytolchinsky.substack.comLatest Issues
The ghost of biomarkers
We do not have reliable, clinically actionable diagnostic biomarkers in psychiatry. This is not news. Over a decade ago, major pharmaceutical companies significantly scaled back psychiatric drug development, largely because the search for s...
What is your favorite ism?
In debates about materialism, idealism, dualism, or monism, it would be useful to have the definition of “matter.” Until we have clear, agreed upon criteria for “matter,” the terms “ideal” and “material” remain concepts that can be variably...
The vulnerable contrarians of physics
Ludwig Boltzmann created statistical mechanics and helped physics move past the dogma of strict determinism. He committed suicide at age 62. His student, Paul Ehrenfest, who continued Boltzmann’s work, committed suicide at age 53.
Hug...
A small step with large consequences
Just opening your eyes changes the state of your brain-mind significantly.
Two data points in support of that with some specifics.
First, in this study combining fMRI and PET, Riedl et al. (2016) showed that the act of opening t...
On bright lines and smooth transitions
Daniel Dennett, in his book “From Bacteria to Bach,” makes an important point.
Many phenomena we see in the world are continuous. When we “digitize” them by using a certain system, be it zeros and ones or a specific alphabet, we inevitabl...
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Authors
The writers behind this newsletter.
Clinical psychologist and researcher in Maryland, US.
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