Asymmetric Learning - Pharmaceutical Innovation
Mike ReaInnovations in Pharmaceutical Innovation A blog/ part-work from Mike Rea, CEO of IDEA Pharma, exploring pharmaceutical innovation in general, and more specifically the approach to using the learning process for competitive advantage
| Platform |  | Pricing | Only free issues | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 303 | Founded | 5 years ago | Last Issue | 7 days ago |
| Active | |||||
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ideapharma.substack.comLatest Issues
Acquiring Biotech Innovation: Why Big Pharma’s External Bets Often Outperform Internal Discovery (At Lower Risk-Adjusted Cost)
In the world of pharmaceutical innovation, one truth stands out: the path from molecule to market seems littered with ‘failure’. (Let’s accept that ‘failure’ is a broad category of a lot of things - an opportunity for asymmetry…) We all kno...
You Keep Using That Word
I used this exact image about 15 years ago. Not sure pharma has got better in general. (I’ve failed 😅)
You keep using that word. Innovation.
I do not think it means what pharma think it means.
Thanks for reading Asymmetric Learning - Ph...
Asymmetric Learning from the Shadows: What WWII Spies Teach Pharma About Covers, Tells, and Truth-Seeking
I’ve always been fascinated by stories from war of undercover agents who integrated perfectly into enemy territory. I know from my own language experience that passing as a local would be well beyond me, even at my best. Can you even imagin...
Real-Time Trials, In Vivo CAR-T Bets, and GLP-1 Scale: Asymmetric Learning in Action
In pharma, most “learning” is performative. We design studies that protect the premise more than test it. We delay bad news until it is too late to pivot. We optimise for regulatory checkboxes over asymmetric insight.
But every once in a w...
The Real Enemy Isn’t the TPP - It’s the CPP: Why the Compromise Product Profile Kills Innovation
We (well, I, feverishly…) talk a lot about the Target Product Profile (TPP). I’ve called it a singularly corrupting element in early-phase development, an enemy of innovation, and the reason so many promising assets end up as also-rans.7
B...
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Authors
The writers behind this newsletter.
Was CEO, IDEA Pharma. Pharmaceutical innovation geek. Senior Fellow @fastercures. Author: Pharmaceutical Positioning. My record label: Medical Records. Large, Geordie, dog fan, street-foodie
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