Cardio Trial Files
TrialFilesFree, bimonthly newsletter that summarizes the most significant, practice-changing cardiology randomized controlled trials, straight to your inbox.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 57 | Founded | 3 years ago | Last Issue | 18 days ago |
| Active | |||||
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cardiotrialfiles.substack.comLatest Issues
Cardio Trial Files: Beta-Blocker Discontinuation Post-MI, Early Surgery vs. Conservative Care for Asymptomatic AS, and Immediate vs. Deferred iFR-guided PCI
Discontinuation of Beta-Blocker Therapy after Myocardial Infarction
Choi KH et al. NEJM (March 2026)
Bottom Line: This open-label, randomized, noninferiority trial conducted at 25 centers in South Korea involved 2540 patients with sta...
Cardio Trial Files Throwback Thursday: Ticagrelor vs. Prasugrel in ACS, Culprit-Only vs. Multivessel PCI in Cardiogenic Shock, and FFR-guided PCI vs. OMT in CAD
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
Schüpke S et al. NEJM (September 2019)
Bottom Line: This multicenter, open-label, randomized trial enrolled 4018 patients with acute coronary syndromes undergoing invas...
Cardio Trial Files: Ticagrelor vs. Prasugrel in Diabetes and Multivessel CAD, Rivaroxaban vs. Apixaban Post Catheter Ablation for AFib, and Evolocumab in Patients Without MI or Stroke
Ticagrelor vs Prasugrel in Patients With Diabetes and Multivessel Coronary Artery Disease (TUXEDO-2)
Bangalore S et al. JAMA (February 2026)
Bottom Line: The TUXEDO-2 study is a prospective, open-label, multicenter, randomized clinica...
Cardio Trial Files Throwback Thursday: Darbepoetin Alfa in Anemia + HFrEF, TAVR in Low-Risk Patients, and ICD Pacing
Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure
Swedberg K et al. NEJM (March 2013)
Bottom Line: This randomized, double-blind trial evaluated the effects of darbepoetin alfa on clinical outcomes in 2278 patients w...
Cardio Trial Files: Tirzepatide vs. Dulaglutide in T2DM, Aspirin +/- Ticagrelor in ACS, and K+ for High Risk Ventricular Arrhythmias
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
Nicholls SJ et al. NEJM (December 2025)
Bottom Line: This active-comparator-controlled, double-blind, noninferiority trial evaluated tirzepatide (up to 15...
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Free biweekly newsletter for trainees and staff on General Internal Medicine at Sinai Health that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.
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