Corin Wagen
My personal blog: chemistry, theology, metascience, and whatever else I'm thinking about.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 106 | Founded | 3 years ago | Last Issue | 8 days ago |
| Active | |||||
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cwagen.substack.comLatest Issues
Towards an Anagogical Reading of “Venice Bitch”
TW: profanity, sarcasm, misuse of theological concepts.
Hosea and Gomer, from the Bible Historiale (1372)
There’s something special about “Venice Bitch,” the nine-minute-long song from Lana Del Rey’s 2019 album Norman Fucking Rockwell. Wi...
Small Molecules Have More Information Per Atom Than Biologics
Something I’ve been thinking about recently is the information content of different biomolecules. While small molecules, peptides, antibodies, and oligonucleotides can all be valuable therapeutic assets in various contexts, they’re striking...
Tool Use and "AI Scientists"
The Rebuilding of the Temple is Begun, Gustave Doré (1866)
As AI systems get more powerful and better at scientific tasks, what will the new research ecosystem look like?
One perspective, which is rarely stated explicitly but comes up imp...
Multiparameter Compound Optimization with LLMs
Yesterday, an interesting paper was released by Prescient Design (Genentech), “Evaluating the Progression of Large Language Model Capabilities for Small-Molecule Drug Design.” The authors formulate a variety of problems in small-molecule dr...
Book Review: The Reformation As Renewal
Martin Luther in the Circle of Reformers (1600s)
TW: stridently anti–Roman Catholic rhetoric, medieval realist metaphysics
Popular histories of the Reformation typically emphasize the discontinuity between medieval theology and the Reform...
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Authors
The writers behind this newsletter.
☧, husband/father, computational/organic chemist
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