Creative Destruction
Carter WilliamsHarnessing the forces of Creative Destruction. How business, finance, and technology industries drive prosperity and improve the human condition.
| Platform |  | Pricing | Freemium | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 182 | Founded | 6 years ago | Last Issue | 5 days ago |
| Active | |||||
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creativedestruction.substack.comLatest Issues
Where the Blood Goes
Two drugs earned $71 billion in 2025. Semaglutide and tirzepatide. More than double OpenAI and Anthropic combined. Tirzepatide is now the best-selling pharmaceutical on earth, and both did it, reaching under 2% of the people who qualify.
I...
I, Pencil
We seem to have a sudden rash of interest in socialism, which is a great opportunity for both sides to do a bad job of explaining socialism and capitalism.
A quick reminder. Capitalism is often defined as a capital-controlling means of pro...
Physics is Law, Creative Destruction is the Natural Order
Stephen Moore writes,
Creative destruction is capitalism’s superpower. The Dow Jones is the perfect example: 30 companies in 1976. Only 1 remains today. Free markets do not preserve the past. They create the future!
He’s right. One name...
The Endowment Effect
Roberto Serrano teaches welfare economics and social choice theory at Brown. The field studies how a group with different wants agrees on one thing. Take an election. How do millions who agree on nothing settle on one candidate?
Serrano’s...
The Utility of Genius
The models arrived in a heap this week. Grok 4.5 landed as an Opus-class model at roughly sixty percent less than Opus. Anthropic shipped, OpenAI moved its next release toward the door, and a couple of open-weight labs matched last year’s f...
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| Subscribers | Engagement | 71 | Monthly Web Visits | ||
|---|---|---|---|---|---|
| Accepts Sponsors | Estimated Cost per Ad | ||||
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Authors
The writers behind this newsletter.
Helping cut healthcare costs from poor nutrition. Sharing insights to drive innovation in Ag, Food, and Health. MD at iSelect, backing 70+ "Food is Health" firms. Ex-Boeing Phantom Works, IoT pioneer (Gridlogix), MIT Sloan, F/A-18 E/F engineer.
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