Creative Destruction
Carter WilliamsHarnessing the forces of Creative Destruction. How business, finance, and technology industries drive prosperity and improve the human condition.
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 176 | Founded | 6 years ago | Last Issue | a month ago |
| Active | |||||
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creativedestruction.substack.comLatest Issues
The Rent-Seeker’s Regulation
In July 2025, Replimune’s melanoma drug RP1 got its first rejection from the FDA. The stock fell 77 percent in a single day. About $3 billion in market cap vanished.
Nine months later, on April 15, 2026, the agency rejected it again. The s...
You Can Buy Lilly's Next Obesity Drug Today for $25
The 40 Amino Acid Line
You can buy Eli Lilly’s next obesity drug online today. Retatrutide is not approved. Lilly is suing FDA over how to classify it. A compounding pharmacy in Florida or a research chemical site in Shenzhen will ship...
Breaking 4%: The Organizational Architecture of Abundance
Jack Dorsey fired 4,000 people and published a manifesto explaining why.
The popular reading is that AI replaces middle managers. That is the least interesting interpretation of what happened. Dorsey just made the first large-scale public...
The Most Effective WMD Isn’t Nuclear. It’s Famine
Presidents are ephemeral. Food, energy, and finance are not
Every few years, Americans get trapped in the wrong frame. They watch a president, a strike, a headline, a tweet, and assume history has suddenly lurched off course. It has no...
What I learned this Week: March 14, 2026
Lessons of the Week
Over Christmas break I finally dug in and started using AI coding tools. Since then, the tools have dominated my thinking of what is possible. Good, bad, and complex. Tools to remove friction. Rethinking markets.
C...
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Authors
The writers behind this newsletter.
Helping cut healthcare costs from poor nutrition. Sharing insights to drive innovation in Ag, Food, and Health. MD at iSelect, backing 70+ "Food is Health" firms. Ex-Boeing Phantom Works, IoT pioneer (Gridlogix), MIT Sloan, F/A-18 E/F engineer.
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