De Novo
MetacelsusAll things synthetic.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 83 | Subscribers | Read | denovo.substack.com |
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Latest Issues
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Reproductive Biology for Politicians and Voters, Part 1
After the results of the 2024 election, it seems that over the next few years, politicians in the USA will seek to pass legislation regulating various issues of human reproduction and developmental biology. My goal in writing this post is t...
This is why we can't have nice things
Last week I was trying to get access to some single cell RNA sequencing (scRNAseq) data hosted at the European Genome-Phenome Archive. Unlike the American databases (SRA and GEO, both hosted at NCBI), where scRNAseq data is pretty easy to d...
SeqVerify: peace of mind for genome engineers
Generating gene-edited cell lines has never been easier — over the last decade, a huge proliferation of tools (CRISPR, base editing, prime editing, engineered transposases and recombinases, etc) have allowed researchers to make defined gene...
Biology needs better visualizations
Gastrulation is one of the most fundamental processes in developmental biology, but up until a few years ago, I didn’t really understand it.1 How does cell differentiation relate to the morphological changes in the embryo? And why are the e...
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