Diabetes Trial Files
TrialFilesFree bimonthly newsletter that summarizes the most significant, practice-changing diabetes randomized controlled trials, straight to your inbox.
| Platform |  | Pricing | Only free issues | Publishes | Monthly |
|---|---|---|---|---|---|
| Issues | 23 | Founded | 2 years ago | Last Issue | 2 months ago |
| Active | |||||
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diabetestrialfiles.substack.comLatest Issues
Diabetes Trial Files Throwback Thursday: Intensive BP Control, Finerenone in CKD+T2DM, and Lifestyle Interventions
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes
Bi Y et al. NEJM (November 2024)
Bottom Line: This randomized trial (BPROAD) enrolled 12,821 adults with type 2 diabetes, elevated systolic blood pressure, and increase...
Diabetes Trial Files: Finerenone in T1DM+CKD, Orforglipron vs. Semaglutide in T2DM, and a Fourth Antidiabetic Drug vs. Metformin Uptitration
Finerenone in Type 1 Diabetes and Chronic Kidney Disease
Heerspink HJL et al. NEJM (March 2026)
Bottom Line: This phase 3 trial evaluated the efficacy and safety of finerenone in adults with type 1 diabetes and chronic kidney disease...
Diabetes Trial Files Throwback Thursday: Tirzepatide in Obesity, Tirzepatide vs. Semaglutide in T2DM, and Dapagliflozin in HFrEF
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff AM et al. NEJM (June 2022)
Bottom Line: This phase 3, double-blind, placebo-controlled trial enrolled 2539 adults with obesity (BMI ≥30, or ≥27 with at least one weight-r...
Diabetes Trial Files: Tirzepatide + Basal Insulin, Empa in GDM, and Mifepristone in T2DM + Hypercortisolism
Efficacy and safety of tirzepatide added to basal insulin in patients with type 2 diabetes in China (SURPASS-CN-INS)
Guo L et al. The Lancet Diabetes & Endocrinology (December 2025)
Bottom Line: The SURPASS-CN-INS trial was a phase 3,...
Diabetes Trial Files Throwback Thursday: Intensive Glycemic Therapy in T2DM, Captopril in T1DM Nephropathy, and CABG/PCI vs. OMT in T2DM with CAD
Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
Duckworth W et al. NEJM (January 2009)
Bottom Line: This randomized controlled trial, conducted on 1791 military veterans with suboptimal response to therapy...
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Free biweekly newsletter for trainees and staff on General Internal Medicine at Sinai Health that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.
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