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We write about frontier advances in the life sciences, machine learning, and technology, and how their fusion is reshaping the trajectory of life on Earth.

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Latest Issues

On the Foundations of Machine Reasoning

Introduction

It’s in the name—artificial intelligence (AI). Since the 1956 AI conference at Dartmouth, researchers have sought to install aspects of the human mind—perception, logic, reasoning—into machine systems.

Humans and computers...

5 months ago
8
1

Pretraining: The First Scaling Frontier

Introduction

It’s hard to imagine that ChatGPT is only three years old. Its release marked a defining inflection point for the adoption of artificial intelligence (AI). In its wake, AI has become one of the most debated, romanticized, an...

5 months ago
14
2

Neuroinflammation: Rethinking Treatment of Brain Disorders

Introduction

Over the past few decades, few therapeutic areas have drawn as much skepticism across biopharma, research, and investment circles as neurology.

When looking at the numbers, this hesitation may be warranted. The average prob...

9 months ago
18
5

ASCO 2025: Themes & Takeaways

Context

Members of our team recently spent a week in Chicago for the American Society of Clinical Oncology (ASCO) 2025 conference. We attended poster sessions, walked the exhibition floor, and listened to many structured sessions. Below...

a year ago
6

Enlicitide: A Curious(er) Macrocycle

Background

Earlier this week, Merck hinted at positive interim results from several ongoing Phase 3 clinical trials evaluating the efficacy of enlicitide, the company’s oral PCSK9 inhibitor. As some have pointed out on Twitter, enlicit...

a year ago
5

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  • Simon Barnett
  • Frank Gao
  • Bauer LeSavage

    Research Associate @ Dimension

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