First Patient In
Paul IvsinPatient enrollment best practices, worst practices, and just plain weird practices
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 34 | Founded | a year ago | Last Issue | 14 days ago |
| Active | |||||
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firstpatientin.substack.comLatest Issues
Can We Do Better?
Probably the most controversial opinion I have is: Actually, drug trials are doing pretty OK. No one likes to hear this!
Have I not seen the stats? Protocol complexity is skyrocketing. Vastly more data is being collected.
Have I not heard...
(Less) Silly Vendor Math
A couple weeks ago I wrote about the practice of recruitment vendors publishing case studies that included an ROI of “time saved” on the trial due to their contribution to enrollment.
In that post, I included a couple of possible alternati...
A Pivotal Trial is a Sailing Tortoise
“Festina Lente” was the motto of the Roman emperor Augustus. Literally, “make haste, slowly”, it conveys the idea that speed is only useful when it’s guided by deliberate and careful thought. “That which has been done well,” he was said to...
Silly Vendor Math
Predicting what would have happened (the counterfactual past) is almost as hard as predicting the future. But we have options.
Two things that recruitment vendors tend to learn about sponsor teams pretty quickly:
First: decision makers ab...
In Startup, What Sites Want Doesn't Exist
There is, of course, something quite surreal about sponsor/site relationships.
A protocol is a set of instructions for a set of highly standardized procedures. Sponsors go to market to sign contracts – highly structured descriptions of per...
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