First Patient In
Paul IvsinPatient enrollment best practices, worst practices, and just plain weird practices
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 32 | Founded | a year ago | Last Issue | 6 days ago |
| Active | |||||
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firstpatientin.substack.comLatest Issues
A Pivotal Trial is a Sailing Tortoise
“Festina Lente” was the motto of the Roman emperor Augustus. Literally, “make haste, slowly”, it conveys the idea that speed is only useful when it’s guided by deliberate and careful thought. “That which has been done well,” he was said to...
Silly Vendor Math
Predicting what would have happened (the counterfactual past) is almost as hard as predicting the future. But we have options.
Two things that recruitment vendors tend to learn about sponsor teams pretty quickly:
First: decision makers ab...
In Startup, What Sites Want Doesn't Exist
There is, of course, something quite surreal about sponsor/site relationships.
A protocol is a set of instructions for a set of highly standardized procedures. Sponsors go to market to sign contracts – highly structured descriptions of per...
Are Real-Time Trials even real?
What finally pushed me over the edge was a single sentence:
“The FDA-facing output is predefined signal metadata tied to the agreed schema.”
That’s a quote from Kent Thoelke, CEO of Paradigm Health, on the data that’s being transmitted to...
Shoddy Regs Make for Shoddy Ads?
I have a new article up over on Clinical Leader: Clinical Trial Ads, Informed Consent, And Half-Hearted Regulation. It’s a bit longer, more detailed, and slightly more polite1 than my usual pieces on Substack – deliberately so, as it’s a to...
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