Francesco Orsi
Brief opinions on various matters
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 71 | Founded | 2 years ago | Last Issue | 8 days ago |
| Active | |||||
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Proven. Again.
In 1984 a medicine could come off patent in America and simply stay uncopied, and for two thirds of the best selling drugs in the country that is exactly what happened [1].
The chemistry was public, the synthesis had been published decades...
Paid in People
Sometime in 2019 4744 people agreed to swallow a pill that might be bringing nothing. Three years later 6263 more people did the same thing, with the same pill, in the same disease, for many of the same investigators, and published in the s...
More Molecules, Fewer Medicines
The new frontier of drug discovery is 30 months. That is how long it took a machine to name a target, design a drug against it, and watch it work in patients [1]. That job used to run six to eight years.
The molecule, rentosertib, is doing...
Necessary, Not Sufficient
In October 2024 the Nobel Prize in Chemistry went, in part, to the people who built AlphaFold [1]. A prize is close to the highest proof that science awards, and this one was earned. So it is worth asking, quietly and without taking anythin...
A Tale of Two Right Answers
In September 1999, a spacecraft arrived at Mars after nine months in transit and flew straight into the planet.
It did not fail because anyone made a mistake. That is the part worth sitting with. The Mars Climate Orbiter [1] was built by s...
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Authors
The writers behind this newsletter.
Bridging tech and healthcare with mathematical precision. As a Data Science Manager, I design the foundational math governing AI and clinical risk, grounded in real-world Pharma case studies.
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