Francesco Orsi
Brief opinions on various matters
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 73 | Founded | 2 years ago | Last Issue | 34 hours ago |
| Active | |||||
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The Agentic Road - AI Costs but Checking is (sort of) Free!
First things first before diving again into AI - This is the final series of the year, which seems like a reason to say what the earlier ones were about before starting it.
This year I tried to change the way I dealt with this blog, and I...
Smarter Models... for the Same Patients
In a vault at Sèvres, behind three locks and under three glass bell jars, there is a cylinder of platinum and iridium about the size of a plum. From 1889 until seven years ago it was the kilogram. Not the official kilogram or the best avail...
Proven. Again.
In 1984 a medicine could come off patent in America and simply stay uncopied, and for two thirds of the best selling drugs in the country that is exactly what happened [1].
The chemistry was public, the synthesis had been published decades...
Paid in People
Sometime in 2019 4744 people agreed to swallow a pill that might be bringing nothing. Three years later 6263 more people did the same thing, with the same pill, in the same disease, for many of the same investigators, and published in the s...
More Molecules, Fewer Medicines
The new frontier of drug discovery is 30 months. That is how long it took a machine to name a target, design a drug against it, and watch it work in patients [1]. That job used to run six to eight years.
The molecule, rentosertib, is doing...
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Authors
The writers behind this newsletter.
Bridging tech and healthcare with mathematical precision. As a Data Science Manager, I design the foundational math governing AI and clinical risk, grounded in real-world Pharma case studies.
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