Ground Truths
Eric Topol, Roxanne Khamsi, Joanna Stern, Marios Georgakis, Elisa Port, Don Milton, Bad Influence, Machine Readable, Aaron Newman, Helen Pearson, Sarah Urbut, MD PhD, Julia Belk, Nathan ZemkeFacts, data and analytics about biomedical matters
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 286 | Founded | 5 years ago | Last Issue | 6 days ago |
| Active | |||||
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erictopol.substack.comLatest Issues
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Loss of Cell Identity Drives Human Aging
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The Big Holes in Wearable Heart Rate Variability And Readiness Scores
On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping it...
Marios Georgakis: Why Did Two Major Clinical Trials for Heart Disease Fail?
In recent weeks the results (announced by press release) of 2 major placebo-controlled randomized trials—ZEUS, testing an interleukin-6 (IL-6) blocker vs inflammation, and HORIZON, testing a drug to lower Lp(a), indicated failure to achieve...
The Coronary Artery Inflammation Controversy
Why did a big clinical trial that tested an anti-inflammatory drug fail to reduce heart events?
Why did another pivotal trial of lowering Lp(a) fail to reduce heart events?
In this edition of Ground Truths I’ll offer some explanations an...
Key Facts
Audience Metrics
Subscribers, engagement, traffic and sponsorship for Ground Truths.
| Subscribers | Engagement | 83 | Monthly Web Visits | ||
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| Ranked Keywords | 8.3k | Monthly Search Traffic | Top Keywords |
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Authors
The writers behind this newsletter.
physician-scientist, author, editor
Roxanne Khamsi is an author and science communicator who has been covering discoveries in genetics and medicine for two decades. Currently, she is a contributing writer for The Atlantic. Her new book is Beyond Inheritance: (Riverhead, 2026).
I'm the founder and chief everything officer at New Things. Subscribe at https://thenewthings.com/subscribe. I'm also the author of I AM NOT A ROBOT: MY YEAR USING AI TO DO (ALMOST) EVERYTHING. Buy it here! https://joannastern.com/
Physician-scientist leading a lab at LMU Munich. Writing about human genetics, drug development, and the future of biotech and medicine.
Chief of breast surgery, Mount Sinai Health System. Author of the forthcoming book, The Breast Advice: All You Need to Know About Health, Screening, and Treatment coming May 19 and available for preorder now. Link below.
Physician, epidemiologist, aerobiologist focused on prevention of airborne infection transmission. @donmilton.bsky.social
Paul A. Volcker Senior Fellow for International Economics at the Council on Foreign Relations. Latest book: The Infinity Machine: Demis Hassabis, DeepMind, and the Quest for Superintelligence. Cohost of The Spillover podcast.
Associate Professor at Stanford University and CZ Biohub Investigator.
I'm a physician scientist at Massachusetts General Hospital and Instructor at Harvard Medical School. I'm passionate about bayesian statistics, genomics, and taking great care of patients. Views are my own.
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