Ground Truths
Eric Topol, Helen Pearson, Don Milton, Aaron Newman, Sarah Urbut, MD PhD, Vadim Gladyshev, Elisa Port, Bad Influence, Nathan Zemke, Michael Lewis, Joanna Stern, Marios Georgakis, Julia BelkFacts, data and analytics about biomedical matters
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 288 | Founded | 5 years ago | Last Issue | 6 days ago |
| Active | |||||
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erictopol.substack.comLatest Issues
Vadim Gladyshev and the Science of Aging
Vadim Gladyshev, PhD, Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School, elected to the National Academy of Science, is a prolific science of aging researcher. We covered many topics including:
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Connecting Our Immune System and Healthspan
In the journal Immunity a paper with an obscure title was published on October 9th, 2026. It was entitled “Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health...
Michael Lewis: The NIH “Murder Mystery,” DOGE, and Our Government Immune System
Michael Lewis is one of the best storytellers of our era. You know and likely have read his books Moneyball, The Big Short, The Blind Side, Flash Boys, Liar’s Poker, and The Undoing Project, to name a few. He has long been one of my favorit...
Loss of Cell Identity Drives Human Aging
Two new papers, one published today in Nature by Vadim Gladyshev and colleagues at Harvard, and a recent one in Cell by Juan Carlos Izpisua Belmonte and his team at Altos Labs, have provided a new model for the biology of aging, and what mi...
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
On September 9th, Apple announced it was revamping its Apple Watch Health Sensing System, rolling out a Readiness score (0 to 10), and increasing the frequency of heart rate variability (HRV) outputs 24-fold. This can be viewed as upping it...
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Authors
The writers behind this newsletter.
physician-scientist, author, editor
Physician, epidemiologist, aerobiologist focused on prevention of airborne infection transmission. @donmilton.bsky.social
Associate Professor at Stanford University and CZ Biohub Investigator.
I'm a physician scientist at Massachusetts General Hospital and Instructor at Harvard Medical School. I'm passionate about bayesian statistics, genomics, and taking great care of patients. Views are my own.
Professor, Brigham and Women' Hospital, Harvard Medical School
Chief of breast surgery, Mount Sinai Health System. Author of the forthcoming book, The Breast Advice: All You Need to Know About Health, Screening, and Treatment coming May 19 and available for preorder now. Link below.
Get my new book “Blockers: Rebels in the Deep State,” out October 6th
I'm the founder and chief everything officer at New Things. Subscribe at https://thenewthings.com/subscribe. I'm also the author of I AM NOT A ROBOT: MY YEAR USING AI TO DO (ALMOST) EVERYTHING. Buy it here! https://joannastern.com/
Physician-scientist leading a lab at LMU Munich. Writing about human genetics, drug development, and the future of biotech and medicine.
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