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Heme Onc Trial Files

TrialFiles

Free monthly newsletter that summarizes the most significant, practice-changing heme-onc randomized controlled trials, straight to your inbox.

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Latest Issues

Heme Onc Trial Files Throwback Thursday: RVD + ASCT + Lenalidomide, Carfilzomib-Dex +/- Isatuximab, and Lenalidomide Post ASCT in MM

Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma

Richardson PG et al. NEJM (June 2022)

Bottom Line: This phase 3 randomized trial (DETERMINATION) enrolled 722 adults aged 18–65 years with newly diagnosed...

4 days ago

Heme Onc Trial Files: Asciminib in CML, Orca-T vs. Allo-HSCT, and Fixed-Duration vs. Continuous Therapy in CLL

Asciminib demonstrates superior efficacy and safety in newly diagnosed chronic myeloid leukemia (ASC4FIRST)

Cortes JE et al. Blood (March 2026)

Bottom Line: This phase 3 randomized trial (ASC4FIRST) evaluated asciminib versus investiga...

a month ago
1

Heme Onc Trial Files Throwback Thursday: DA-EPOCH-R vs R-CHOP, DA-EPOCH-R in MYC-Rearranged Disease, and De-escalation in Favorable-Risk DLBCL

Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cell Lymphoma: Clinical Outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303

Bartlett NL et al. J Clin Oncol (April 2019)

Bottom Line: This...

2 months ago
2

Heme Onc Trial Files: Epcoritamab-R² in Follicular Lymphoma, Venetoclax in t(11;14) Myeloma, and CAR-T Durability in LBCL

Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1)

Falchi L et al. Lancet (January 2026)

Bottom Line: This multicountry, open-label, phase 3 trial ev...

3 months ago
1

Heme Onc Trial Files Throwback Thursday: Brentuximab Vedotin+AVD, PET-Guided Therapy, and Nivolumab+AVD in Advanced Hodgkin’s Lymphoma

Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma

Connors JM et al. NEJM (January 2018)

Bottom Line: This open-label, multicenter, randomized phase 3 trial involved 1334 patients with previously untreated st...

4 months ago
3

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  • TrialFiles

    Free biweekly newsletter for trainees and staff on General Internal Medicine at Sinai Health that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.

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