My personal Substack
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 43 | Founded | a year ago | Last Issue | 9 days ago |
| Active | |||||
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yassinelab.orgLatest Issues
Lithium Orotate, APOE4, and Alzheimer Prevention
A 60-year-old woman recently came to see me for a second opinion.
She carries two copies of APOE4, and her mother developed dementia. Since learning her genotype, she has been doing many of the things we would normally recommend for brain...
Hearing Loss, APOE4, and Dementia
Hearing loss is usually thought of as a problem of the ears. Conversations in restaurants become harder to follow, the television gets louder, and people begin asking others to repeat themselves.
But hearing loss has also emerged as one of...
Alcohol, APOE4, and the Brain
A 56-year-old woman recently learned that she carries two copies of APOE4, the strongest common genetic risk factor for late-onset Alzheimer disease.
Both of her grandparents had developed dementia.
She was already doing many of the thing...
APOE4, Inflammation, and Cognitive Decline
We recently published a study examining how brain lipid pathways related to inflammation are associated with cognitive decline late in life. Using postmortem brain tissue from participants in the Religious Orders Study and Rush Memory and A...
Do Brain Games Prevent Dementia?
A reporter recently contacted me while working on a story about the latest evidence on brain games and dementia prevention. Her questions were straightforward: Do these programs actually work? Which types have evidence? Are commercial apps...
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Authors
The writers behind this newsletter.
I am the Volke Endowed Professor of Neurology at USC and Vice Chair. I direct the Center for Personalized Brain Health. Interested in APOE ε4, lipid metabolism, and dementia risk. I stand for reproducible science: humanist and mentor.
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