Hypothesis Next
Hypothesis Next explores the intersection of science, health, and the forces that shape social and financial capital.
| Platform |  | Pricing | Only free issues | Publishes | Daily |
|---|---|---|---|---|---|
| Issues | 12 | Founded | 4 months ago | Last Issue | 21 days ago |
| Active | |||||
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hypothesisnext.substack.comLatest Issues
From GitHub to Genomes: Inside Big Tech’s Software Harness for Science
NVIDIA used its BIO2026 keynote to argue that agentic AI is about to do for drug discovery what it has done for software engineering: multiply output by wiring large language models into a harness of scientific tools.
The evidence for this...
The True Cost of NIH's New Ideological Filters
The new political screening of NIH grants described by Nature should worry anyone who cares about science, biotech or long-term returns. According to the report, hundreds of grant applications that have already passed peer review are now st...
Beyond the Headline: What FDA TrialBlazer Actually Means for Clinical Biotech
tl;dr
On 22 June 2026 the FDA published a package of actions under Operation TrialBlazer, the HHS initiative to speed drug development from the IND stage to late-stage pivotal trials.
The headline proposals are
- a clarification tha...
A checklist for reading press releases in biotech investing
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Compare the press release against the trial registration and any published paper.
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Check whether the primary endpoint was met, and whether the abstract accurately reflects that result.
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Check absolute numbers, not just relative...
8 more tips for understanding trial results in biotech investing
In Part 1 I gave you the read on endpoints, significance, and how to spot the real data not the story the company is selling.
Part 2 focuses on how the framing of the results seeks to tell a story, the biases we see that can affect real wo...
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The intersection of health, wealth and science.
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