James H. Stein, MD
I’m a preventive cardiologist and professor with over 35 years caring for patients and researching cardiovascular disease. I aim to make health and science clearer and more approachable. *Not* monetized. My views, not medical advice.
| Platform |  | Pricing | Only free issues | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 73 | Founded | a year ago | Last Issue | 6 days ago |
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jamesstein18.substack.comLatest Issues
Multi-Cancer Early Detection Tests: Misleading in Both Directions
Image credit: UT MD Anderson
There is a particular kind of medical wishful thinking that is almost impossible to argue against in the exam room. A patient comes in having read about a new blood test that screens for fifty different cancers...
When the First Trial Fools Us
Note to readers: Starting this Wednesday, and for the rest of July, my posts will be directed more toward a broader audience of patients, families, and anyone curious about their health. I will continue to post clinical and research-focused...
How I Read a Randomized Clinical Trial Before I Believe It
We all are busy and reading medical research studies is time-consuming, so I understand the impulse to just read the abstract and skim the conclusion. I do that sometimes. But that is how we get misled, since many trials are not well design...
Worn Out by Wearables (Redux)
Note: When I wrote about wearables last year, not many of you were here yet. Since then, new data have appeared. This substantially revised post focuses on the metrics themselves: what the devices actually measure, how well they measure it,...
You’ve Won the Game
My parents. Photo credit: Phil Kidd, MKE Lifestyle, May 2026
When a patient has made it to 85 years old in reasonable health, their instinct - and often their physician’s - is to redouble prevention efforts, optimize every number, and clos...
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I’m a preventive cardiologist and professor with over 36 years experience caring for patients and researching cardiovascular disease. I aim to make health and science clearer and more approachable. *Not* monetized. My views, not medical advice.
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