James H. Stein, MD
I’m a preventive cardiologist and professor with over 35 years caring for patients and researching cardiovascular disease. I aim to make health and science clearer and more approachable. *Not* monetized. My views, not medical advice.
| Platform |  | Pricing | Only free issues | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 69 | Founded | a year ago | Last Issue | 7 days ago |
| Active | |||||
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jamesstein18.substack.comLatest Issues
You’ve Won the Game
My parents. Photo credit: Phil Kidd, MKE Lifestyle, May 2026
When a patient has made it to 85 years old in reasonable health, their instinct - and often their physician’s - is to redouble prevention efforts, optimize every number, and clos...
Curious Cholesterol Cases From Clinic, #4: A Young Man With Xanthomas and the Wrong Diagnosis
“Curious Cholesterol Cases from Clinic” is a series built around real-world lipid cases, some of which look obvious at first glance but turn out not to be what they seem. They are presented as clinical unknowns for teaching purposes and are...
The Medicine I Trained In No Longer Exists
Despite my interest in critical appraisal of medical literature and the need to teach it to future physicians and researchers, I regularly find myself stepping back to remember how far medicine has come since my training. I tell my trainees...
What I Finally Optimized on My Bike Ride
The Joys and Torments of Solitude, Jean-Jacques Sempé, The New Yorker, August 2, 2010
Like most people, I learned to ride a bike when I was a child, but my relationship to it always was practical: finding friends to play with and getting f...
Why “Cholesterol Is Debunked” Arguments Keep Resurfacing
I am starting this essay with a picture.
MRFIT mortality data, drawn from Table 4 of reference 1.
It comes from the Multiple Risk Factor Intervention Trial (1), a study of more than 350,000 middle-aged men, conducted at a time when women...
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I’m a preventive cardiologist and professor with over 35 years caring for patients and researching cardiovascular disease. I aim to make health and science clearer and more approachable. *Not* monetized. My views, not medical advice.
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