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Joseph Raffaele

Physician-Scientist in Longevity Medicine | Health Analytics Entrepreneur

Platform
Substack
PricingOnly free issuesPublishesWeekly
Issues15Foundeda year agoLast Issuea month ago
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Latest Issues

Is the Longevity Peptide Movement Over its Skis?

There is a metaphor skiers use when someone is leaning too aggressively downhill, pushing faster than their balance and technique can safely support. They say the skier is “over their skis.”

Lately I’ve realized this perfectly captures muc...

a month ago
9
1

My reaction to the recent New York Times Magazine piece on testosterone...

“The Testosterone Moment is Here. And Men May Never Look the Same” (May 12) is a classic case of “on the one hand, but on the other.” On the one hand, I don’t think I’ve ever read a piece in the mainstream media with as many glowing anecdot...

2 months ago
9
2

The Most Underappreciated Longevity Biomarker: Urine Albumin

If you had to choose a single biomarker that reflects the integrity of your microvasculature—the health of the smallest blood vessels that sustain every organ system—it likely wouldn’t be a urine test.

But it probably should be.

Urine alb...

4 months ago
6

Does the Glycocalyx Explain the HRT Timing Hypothesis?

For more than two decades, we’ve wrestled with the Women’s Health Initiative.

Estrogen was supposed to protect the heart. Observational data suggested it did. Yet according to the data released by the WHI in 2002, hormone replacement thera...

6 months ago
5
4

Plasmalogens, Controversy, and Scientific Middle Ground: A Response to Christin Glorioso, MD, PhD

First, I want to thank you for taking the time to examine this topic seriously in your Substack article recently. Your piece raises important concerns, and I agree with much of your framing. Where I differ is primarily in emphasis rather th...

6 months ago
10
4

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