Joseph Raffaele
Physician-Scientist in Longevity Medicine | Health Analytics Entrepreneur
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 13 | Founded | 9 months ago | Last Issue | 2 months ago |
| Active | |||||
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josephraffaele329336.substack.comLatest Issues
The Most Underappreciated Longevity Biomarker: Urine Albumin
If you had to choose a single biomarker that reflects the integrity of your microvasculature—the health of the smallest blood vessels that sustain every organ system—it likely wouldn’t be a urine test.
But it probably should be.
Urine alb...
Does the Glycocalyx Explain the HRT Timing Hypothesis?
For more than two decades, we’ve wrestled with the Women’s Health Initiative.
Estrogen was supposed to protect the heart. Observational data suggested it did. Yet according to the data released by the WHI in 2002, hormone replacement thera...
Plasmalogens, Controversy, and Scientific Middle Ground: A Response to Christin Glorioso, MD, PhD
First, I want to thank you for taking the time to examine this topic seriously in your Substack article recently. Your piece raises important concerns, and I agree with much of your framing. Where I differ is primarily in emphasis rather th...
The Glycocalyx: The Invisible Sugar Layer That May Decide How Fast We Age
When most people think about heart disease and aging blood vessels, they imagine clogged arteries, cholesterol plaques, or stiff vessel walls. That picture isn’t wrong—but it is incomplete.
Before cholesterol ever sticks, before arteries s...
Hormone Replacement Therapy as Geroprotective Medicine
A new paper has entered the longevity medicine conversation with unusual ambition and welcome clarity: Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach – Adapting Clinical Guidance. Its central claim is both bold a...
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