Joseph Raffaele
Physician-Scientist in Longevity Medicine | Health Analytics Entrepreneur
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 16 | Founded | a year ago | Last Issue | 14 days ago |
| Active | |||||
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josephraffaele329336.substack.comLatest Issues
GLP-1s and Muscle Loss: What the Headlines Get Wrong
As the GLP-1 drugs become ever more available, they’ve been dogged by a nagging concern – loss of muscle. It’s a common red flag waved on social media and it undoubtedly contributes to the high drop-off rate we’ve seen in GLP-1 prescription...
Is the Longevity Peptide Movement Over its Skis?
There is a metaphor skiers use when someone is leaning too aggressively downhill, pushing faster than their balance and technique can safely support. They say the skier is “over their skis.”
Lately I’ve realized this perfectly captures muc...
My reaction to the recent New York Times Magazine piece on testosterone...
“The Testosterone Moment is Here. And Men May Never Look the Same” (May 12) is a classic case of “on the one hand, but on the other.” On the one hand, I don’t think I’ve ever read a piece in the mainstream media with as many glowing anecdot...
The Most Underappreciated Longevity Biomarker: Urine Albumin
If you had to choose a single biomarker that reflects the integrity of your microvasculature—the health of the smallest blood vessels that sustain every organ system—it likely wouldn’t be a urine test.
But it probably should be.
Urine alb...
Does the Glycocalyx Explain the HRT Timing Hypothesis?
For more than two decades, we’ve wrestled with the Women’s Health Initiative.
Estrogen was supposed to protect the heart. Observational data suggested it did. Yet according to the data released by the WHI in 2002, hormone replacement thera...
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