Unrelenting EBM
Kuma FolmsbeeMy personal Substack. Generative AI is not used for any of the writing (including content, grammar or prose)
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 111 | Founded | 2 years ago | Last Issue | 5 days ago |
| Active | |||||
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unrelentingebm.substack.comLatest Issues
The return of the message not being the median
The Median Isn’t the Message. Stephen Jay Gould. Bully for Brontosaurus: Reflections in Natural History by Stephen Jay Gould (c) 1991
Dr. Abrams first recommended the paper to me. Over the years, I’ve come across many like-minded academic...
SNAP Trial! New Academic Year!
The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group. Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia. N Engl J Med 2026;394:2329-39. DOI: 10.1056/NEJMoa2506905
So why this study? At Rush, cefazolin...
The forgotten stepchild–Amiloride. (SPARE Trial)
Lee CJ, Ihm SH, Shin DH, et al. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial. JAMA. 2025;333(23):2073-2082. doi:10.1001/jama.2025.5129
I have never prescribed Amiloride.
This blindspot is related to...
Evidence expiring before publication (Trident)
Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage. N Engl J Med 2026; 394:1571-82
Trident was a randomized controlled trial looking at triple therapy BP pill vs standard of care in specific subset of st...
Perpetual Tyranny of Health
Fitzgerald, F. T. (1994). The Tyranny of Health. The New England Journal of Medicine, 331(3), 196-198
I recently finished reading Independent People by Halldor Laxness. It chronicles the life of an Icelandic sheep herder set in the early 1...
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Internist figuring out critical appraisal. Mostly done for myself but anyone else welcome.
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