Unrelenting EBM
Kuma FolmsbeeMy personal Substack. Generative AI is not used for any of the writing (including content, grammar or prose)
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 103 | Founded | 2 years ago | Last Issue | 3 days ago |
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unrelentingebm.substack.comLatest Issues
Don’t call it a comeback (Digoxin for HFrEF)
Damman K, van Veldhuisen DJ, Bauersachs J, et al. Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis. JAMA. Published online May 10, 2026
The above paper was a meta-analysis of studies looking at digitalis glycos...
Week 205 - AI “defeats” ED docs?
Brodeur, P. G., Buckley, T. A., Kanjee, Z., Goh, E., Ling, E. B., Jain, P., Cabral, S., Abdulnour, R.-E., Haimovich, A. D., Freed, J. A., Olson, A., Morgan, D. J., Hom, J., Gallo, R., McCoy, L. G., Mombini, H., Lucas, C., Fotoohi, M., Gwiaz...
A lot of LDL reduction for a little morbidity reduction (VESALIUS)
Marston NA, Bohula EA, Bhatia AK, et al. Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV Trial. JAMA. 2026;335(16):1400-1407. doi:1...
Medicine is hard
Taglienti, Jenna MD. Time Is Finite. JAMA (Journal of the American Medical Association). Published online April 16, 2026. DOI: 10.1001/jama.2026.3656
The poignant piece is about a physician’s experience getting the diagnosis of cancer and...
IMPACTS-BP - An Army for the underserved
Mills KT, Krousel-Wood M, Peacock EM, et al. Multifaceted Strategies for Hypertension Control in Low-Income Patients. N Engl J Med 2026;394:1376-87. DOI: 10.1056/NEJMoa2504068
IMPACTS-BP was a cluster-randomized controlled trial conducted...
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Internist figuring out critical appraisal. Mostly done for myself but anyone else welcome.
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