Unrelenting EBM
Kuma FolmsbeeMy personal Substack. Generative AI is not used for any of the writing (including content, grammar or prose)
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 121 | Founded | 2 years ago | Last Issue | 2 days ago |
| Active | |||||
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unrelentingebm.substack.comLatest Issues
Another sham victory! (PVI-SHAM-AF)
Wachter R, Haag P, Uhe T, et al. Catheter ablation for symptomatic atrial fibrillation (PVI-SHAM-AF): a randomised, double-blind, sham-controlled, multicentre trial. Lancet. doi:10.1016/S0140-6736(26)01558-8
PVI-SHAM-AF was a randomized, d...
An amateur superficial rant about semantics
Is chronic kidney disease a risk factor or a disease state?
What is the difference between a risk factor and disease? You could say (academically and idiotically) that the only true disease is death and that life is just full of risk facto...
Indication creep (SINGLE-AF)
Kim D, Lee YS, Shim J, et al. Anticoagulation for atrial fibrillation with intermediate stroke risk (SINGLE-AF). N Engl J Med. 2026;395(9):1-12. doi:10.1056/NEJMoa2607978
SINGLE-AF was an open label randomized controlled trial comparing an...
HPV swab (clinician vs self-swab)
Phillips, S. A., Denoël, S., Wentzensen, N., & Arbyn, M. (2025). Accuracy of HPV self-collection compared with clinician-collected HPV testing and cytology: A meta-analysis. Cancer Epidemiology, Biomarkers & Prevention, 34(9), 1467–1471.
I...
Diagnostic EBM–quietly neglected
Morgan DJ, Korenstein D, Diekema DJ. Moving from laboratory to clinical metrics for diagnostic tests. JAMA Intern Med. Published online August 17, 2026. doi:10.1001/jamainternmed.2026.3784
Diagnostic appraisal remains an important and poor...
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Internist figuring out critical appraisal. Mostly done for myself but anyone else welcome.
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