Unrelenting EBM
Kuma FolmsbeeMy personal Substack. Generative AI is not used for any of the writing (including content, grammar or prose)
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 108 | Founded | 2 years ago | Last Issue | 6 days ago |
| Active | |||||
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unrelentingebm.substack.comLatest Issues
Evidence expiring before publication (Trident)
Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage. N Engl J Med 2026; 394:1571-82
Trident was a randomized controlled trial looking at triple therapy BP pill vs standard of care in specific subset of st...
Perpetual Tyranny of Health
Fitzgerald, F. T. (1994). The Tyranny of Health. The New England Journal of Medicine, 331(3), 196-198
I recently finished reading Independent People by Halldor Laxness. It chronicles the life of an Icelandic sheep herder set in the early 1...
Ensitrelvir (Xocova) - Does it prevent COVID?
Hayden FG, Shinkai M, Clark TW, et al. Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts. N Engl J Med 2026;394:1905-15.
The first paper I read for this little weekly newsletter was the original study on the effective...
Are Glp1a life long medications?
Horn, D. B., Aronne, L. J., Wharton, S., Bays, H. E., le Roux, C. W., Srinath, R., Gomez-Valderas, E., Arad, A. D., Das, S., Dunn, J. P., Ribeiro, A., Glass, L. C., & Lee, C. J. (2026). Tirzepatide for maintenance of bodyweight reduction in...
Delayed development of glp-1a
Drug Development Failure: How GLP-1 Development was abandoned in 1990. Jeffrey S. Flier. Perspectives in Biology and Medicine.
The recap–Dr. Flier was part of a group that worked on a GLP-1a in 1990 when it was shown to lower sugar levels...
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Internist figuring out critical appraisal. Mostly done for myself but anyone else welcome.
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