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Intelligence Infrastructure for Biology

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Latest Issues

VariantBench: An Agentic Benchmark for Genetic Variant Discovery and Interpretation

Analysis of data from genome sequencing and related assays is an increasingly important bottleneck in clinical and research settings. AI agents hold promise in automating and scaling such analysis.

We present VariantBench, a verifiable ben...

9 days ago
61

Why An Open Source Harness Outperforms Claude Code On Frontier Biology Tasks

At LatchBio, we benchmark AI models on frontier-level biology tasks - benchmarks.bio. We’ve seen a trend where harness changes cause large swings in performance on the same model. For example, on TxBench-PP (a short-horizon benchmark), the...

15 days ago
44
3

Benchmarking AI Agents on Pathogen Genomic Surveillance

We introduce BioSecBench-Surveillance, a verifiable benchmark for testing whether AI agents can make the analytical decisions required in pathogen genomic surveillance.

The benchmark contains 100 evaluations spanning seven task categories,...

16 days ago
9
2

Benchmarking Refusals in Agentic Biology

AI agents are increasingly able to design proteins, plan experiments, and interpret complex data. These capabilities present an acute dual-use problem: they can accelerate beneficial discoveries or, if misused, enable harm.

Refusal trainin...

24 days ago
74

Latch MCP: Agent-Native Data Infrastructure

AI for biology requires agent-native infrastructure: systems where agents can store, process, and visualize large molecular datasets from the interfaces scientists already use. Biological tasks downstream of large spatial, single-cell, or p...

25 days ago
8

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Authors

The writers behind this newsletter.

  • LatchBio
  • Kenny Workman

    Co-Founder + CTO @ LatchBio

  • Alfredo Andere

    Co-Founder and CEO @ LatchBio

  • Hannah Le
  • Harihara Muralidharan

    Bioinformatics Engineer @LatchBio

  • Zhen Yang

    Bioinformatics

  • Anirudh Narsipur
  • Joel Simonoff

    AI@LatchBio

  • Dianzhuo Wang
  • Evan Seeyave

    above average mango eater

  • Harmon Bhasin
  • Social

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