Liang's AIxBIO foundry
Liang ChangI'm a Biotech VC, PhD Cancer Biologist, AI enthusiastic and practitioner. I write about AI, biotech, books, podcasts, and everything I learned at the intersection
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 11 | Founded | 4 months ago | Last Issue | 21 days ago |
| Active | |||||
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liangchang.substack.comLatest Issues
The Quest to Drug KRAS: 40 Years, 8,491 Abstracts, 6 Eras, 4 Drugs, 2 Pockets, 1 Pivotal Moment
On April 13, Revolution Medicines reported topline data from RASolute 302, the Phase 3 trial of pan-RAS inhibitor daraxonrasib monotherapy against chemotherapy in 2L metastatic pancreatic cancer patients with KRAS G12X mutations. Median OS...
The Decade in Oncology: What 57,603 ASCO Abstracts Reveal between 2016-2025
Catching up with oncology is like trying to board a bullet train that left the station two years ago. Everything moves so fast. Missing one AACR → ASCO → ESMO cycle = losing the ability to cite the top-line OS/PFS/ORR bars that keep oncolog...
My quick take on Anthropic's new Claude Mythos model: it might change the world forever, for better or for worse
I typically don’t comment on model releases until I run my own evaluations. I benchmark against a set of tasks I actually care about and get an informed opinion, using my “muscle memory” from building multi-step AI agent workflows, in areas...
4 Things My Newborn Taught Me About AI That No Benchmark Will Ever Capture
Before my son arrived, I had an “AI addiction” problem that consumed nearly all my free time outside of work.
A $200/month Claude Max subscription burning through $1,500+/month in API-equivalent value, with ChatGPT, Gemini, and Grok subscr...
Can AI Make Better Decisions Than Pharma Executives? I Tested It on the Biggest Call in Oncology History (on a Time Machine)
Can AI make better decisions than humans?
Not “can AI process data” or “can AI summarize a clinical trial” or “can AI automate a tedious workflow.” We all know the answer to those.
I mean: can AI make the kind of high-stakes decisions tha...
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Biotech VC, Harvard PhD in Cancer Biology, AI enthusiast and practitioner ｜ Write about AI, biotech, books, podcasts, and everything at the intersection
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