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Artwork for Liang's AIxBIO foundry

Liang's AIxBIO foundry

Liang Chang

I'm a Biotech VC, PhD Cancer Biologist, AI enthusiastic and practitioner. I write about AI, biotech, books, podcasts, and everything I learned at the intersection

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Substack
PricingOnly free issuesPublishesWeekly
Issues15Founded9 months agoLast Issue16 days ago
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Artwork for Liang's AIxBIO foundry

Latest Issues

Human Genetics Doubled Drug Development Success. Two Failures This Summer Showed Why It’s a Powerful Foundation, Not The Finish Line.

Liang Chang and Mary Helen Black

Over the past decade, human genetics quietly became the most reliable de-risking tool in drug development. Drug mechanisms with human genetic support have roughly 2 times to 2.6 times the probability of rea...

16 days ago
21
2

Towards Biomedical Superintelligence: from AI agents to AI innovators

Jorge S. Reis-Filho & Liang Chang

Artificial intelligence is approaching its most important transition: from systems that retrieve, reason and execute within an existing evidence base to systems capable of expanding that evidence base thro...

a month ago
22
4

The Anti-Scaling Law in Biology, and Why AI Could Make Crowding Worse Before Making Drug Development Better

In the last two weeks, two clinical trial readouts drew tremendous excitement well beyond the biopharma community.

At the plenary of the world’s largest cancer meeting, a room of oncologists stood and applauded the biggest win in pancreati...

4 months ago
101
13

I Asked 2 AI Agent Teams to Run 20 Biopharma Decisions. They Agreed With Each Other More Than With Reality but Could Save History in Some Cases...

I built an AI agent team as biopharma executives, and sent them to the boardrooms where historical high-stakes strategic decisions took place, on a time machine.

In June 2012, both Claude Opus 4.6 and ChatGPT-5.3 AI agent teams, acting as...

4 months ago
27
3

The Quest to Drug KRAS: 40 Years, 8,491 Abstracts, 6 Eras, 4 Drugs, 2 Pockets, 1 Pivotal Moment

On April 13, Revolution Medicines reported topline data from RASolute 302, the Phase 3 trial of pan-RAS inhibitor daraxonrasib monotherapy against chemotherapy in 2L metastatic pancreatic cancer patients with KRAS G12X mutations. Median OS...

5 months ago
18
3

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  • Liang Chang

    Biotech x AI Builder and VC, Harvard PhD in Cancer Biology, AI enthusiast and practitioner

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