Maria Gutschi
The Offsc℞ipt PharmacistOffscript Pharmacist. Off label analysis from a pharmacist who reads the fine print. Independent researcher. Independent thinker. Wife, mother, grandmother,
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
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| Issues | 98 | Founded | 3 years ago | Last Issue | 2 days ago |
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mariagutschi.substack.comLatest Issues
The Wang study on LNPs and cancer: and the questions it leaves unanswered
A rather heated exchange over a new mouse study reporting that an mRNA-vaccine-type lipid nanoparticle increased metastatic burden. Jeffrey Morris called the paper a “potential mechanistic hypothesis.” JikkyLeaks responded that the investig...
Call2Halt19: The Questions Health Canada Still Has Not Answered
In March 2025, a group of Canadian scientists, clinicians, and other professionals sent an open letter to federal and provincial representatives and public-health officials, raising specific concerns about the quality, safety, and regulatio...
Exosomes, Schmectasomes: The Hidden Second Life of mRNA-LNPs
Exosomes, schmectasomes. It is time I talked about exosomes. I revisited the Onpattro (patisiran) data and was struck by how much research into Onpattro’s regulatory authorization helps us understand mRNA technology and mRNA platform pharma...
Always Early
Image from ChatGPT as per my suggestions
Introduction
I will never forget the forty-year-old trucker. He was driving through Winnipeg where is where I had just started after graduating with a brand new PharmD from the US. He was previo...
Four Questions About mRNA-LNP "Vaccines" That Still Need Answers
Introduction
A few weeks ago, Acta Pharmaceutica Sinica B published a paper I co-authored with Falko Seger and Stephanie Seneff: Lipid nanoparticles as active biointerfaces: From membrane interaction to systemic dysregulation.
What we...
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Authors
The writers behind this newsletter.
Off label analysis from a pharmacist who reads the fine print. Independent researcher. Independent thinker. Wife, mother, grandmother, Catholic.
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