Maria Gutschi
The Offsc℞ipt PharmacistOffscript Pharmacist. Off label analysis from a pharmacist who reads the fine print. Independent researcher. Independent thinker. Wife, mother, grandmother,
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
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| Issues | 100 | Founded | 3 years ago | Last Issue | a month ago |
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One Injection, Five Vehicles: The Plain Language Version
Introduction
When a pharmacist/pharmacologist asks “where does this drug go?” they are asking a pharmacokinetics question. For most drugs like a small-molecule painkiller, a monoclonal antibody, or a conventional vaccine, well, the answ...
Where do the LNPs go? The 5 Body Problem
Update: Fixed the references which were out of order, expanded the Track 3 with more evidence and better framing. (05/10/26 2000h)
This post summarizes about 4 years of work on LNP biodistribution and took several months to write, lol.
#...
The Wang study on LNPs and cancer: and the questions it leaves unanswered
A rather heated exchange over a new mouse study reporting that an mRNA-vaccine-type lipid nanoparticle increased metastatic burden. Jeffrey Morris called the paper a “potential mechanistic hypothesis.” JikkyLeaks responded that the investig...
Call2Halt19: The Questions Health Canada Still Has Not Answered
In March 2025, a group of Canadian scientists, clinicians, and other professionals sent an open letter to federal and provincial representatives and public-health officials, raising specific concerns about the quality, safety, and regulatio...
Exosomes, Schmectasomes: The Hidden Second Life of mRNA-LNPs
Exosomes, schmectasomes. It is time I talked about exosomes. I revisited the Onpattro (patisiran) data and was struck by how much research into Onpattro’s regulatory authorization helps us understand mRNA technology and mRNA platform pharma...
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Authors
The writers behind this newsletter.
Off label analysis from a pharmacist who reads the fine print. Independent researcher. Independent thinker. Wife, mother, grandmother, Catholic.
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