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Adith Arun

Adith Arun

Writing about medicine, biology, stats, and anything in between. Commentary on new medical research, clinical trials, and biotech companies.

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Substack
PricingOnly free issuesPublishesWeekly
Issues18SubscribersRead aditharun.com

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Latest Issues

Recent posts by this newsletter. Browse the email archive.

Interpreting FDA's plausible mechanism pathway draft guidance document

FDA introduced the plausible mechanism pathway a few months ago (NEJM piece). Makary (FDA commissioner) and Prasad (FDA CBER head) wrote the following:

9 days ago
2
0

On halting the progression of frontotemporal dementia

What would a reasonable bar for success look like given that we have no disease modifying therapies available to treat frontotemporal dementia due to a pathogenic progranulin mutation (FTD-GRN)? After a one-time minimally-invasive treatment...

2 months ago
5
8

Clascoterone is not a cure for baldness

Cosmo Pharmaceuticals (OTCMKTS: CMOPF) recently released a press release from their two phase 3 studies of clascoterone in male pattern hair loss. Here is the clipping and the full link can be found here.

3 months ago
1
0

Semaglutide in early-stage Alzheimer's Disease

Novo Nordisk is presenting top line results from their EVOKE and EVOKE+ trials at CTAD on December 3 at 5:05 pm PST. EVOKE and EVOKE+ are two trials evaluating oral once-daily semaglutide against placebo in early symptomatic Alzheimer’s Dis...

4 months ago
5
2

Authors

The writers behind this newsletter.

  • Adith Arun

    Writing at the intersection of medicine and statistics

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