Adith Arun
Writing about medicine, biology, stats, and anything in between. Commentary on new medical research, clinical trials, and biotech companies.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 19 | Founded | 4 years ago | Last Issue | 3 months ago |
| Active | |||||
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aditharun.comLatest Issues
Digging into Beam Therapeutics
I started writing this article on X then mid-way through tried to port everything over to Substack but it was such a pain. I figure most of you have X accounts so please click here for the full writeup. Future posts will be Substack native....
Interpreting FDA's plausible mechanism pathway draft guidance document
FDA introduced the plausible mechanism pathway a few months ago (NEJM piece). Makary (FDA commissioner) and Prasad (FDA CBER head) wrote the following:
Once a manufacturer has demonstrated success with several consecutive patients with...
On halting the progression of frontotemporal dementia
What would a reasonable bar for success look like given that we have no disease modifying therapies available to treat frontotemporal dementia due to a pathogenic progranulin mutation (FTD-GRN)? After a one-time minimally-invasive treatment...
Clascoterone is not a cure for baldness
Cosmo Pharmaceuticals (OTCMKTS: CMOPF) recently released a press release from their two phase 3 studies of clascoterone in male pattern hair loss. Here is the clipping and the full link can be found here.
The 539% number has been quoted a...
Semaglutide in early-stage Alzheimer's Disease
Novo Nordisk is presenting top line results from their EVOKE and EVOKE+ trials at CTAD on December 3 at 5:05 pm PST. EVOKE and EVOKE+ are two trials evaluating oral once-daily semaglutide against placebo in early symptomatic Alzheimer’s Dis...
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Writing at the intersection of medicine and statistics
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