Nephro Trial Files
TrialFilesFree bimonthly newsletter that summarizes the most significant, practice-changing nephrology randomized controlled trials, straight to your inbox.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 58 | Founded | 3 years ago | Last Issue | a month ago |
| Active | |||||
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nephrotrialfiles.substack.comLatest Issues
Nephro Trial Files: Finerenone in T1DM+CKD, HTN Control in Low-Income Patients, and Monlunabant in DKD
Finerenone in Type 1 Diabetes and Chronic Kidney Disease
Heerspink HDL et al. NEJM (March 2026)
Bottom Line: This phase 3 trial evaluated the efficacy and safety of finerenone in adults with type 1 diabetes and chronic kidney disease...
Nephro Trial Files Throwback Thursday: Bardoxolone Methyl in CKD + T2DM, Ultrafiltration in HF + Cardiorenal Syndrome, and Rituximab for ANCA-Associated Vasculitis
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
Pergola PE et al. NEJM (July 2011)
Bottom Line: This phase 2, double-blind, placebo-controlled trial enrolled 227 adults with chronic kidney disease (eGFR 20–45 mL/min...
Nephro Trial Files: Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN, AKI After Surgery, and Semaglutide in T2DM
Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN
Fakhouri F et al. NEJM (December 2025)
Bottom Line: This phase 3, double-blind, placebo-controlled trial evaluated the efficacy and safety of pegcetacoplan in 124 ado...
Nephro Trial Files Throwback Thursday: Diuretics in Acute Decompensated HF, Postdilution Online Hemodiafiltration, and Chloride-Liberal vs. Restrictive IV Fluids in the ICU
Diuretic Strategies in Patients with Acute Decompensated Heart Failure
Felker GM et al. NEJM (March 2011)
Bottom Line: This was a randomized controlled trial comparing diuretic strategies in 308 patients hospitalized with acute decomp...
Nephro Trial Files: Conservative Dialysis in Dialysis-Requiring AKI, Pravastatin in ADPKD, and Baxdrostat in Uncontrolled and Resistant Hypertension
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury (LIBERATE-D)
Liu KD et al. JAMA (November 2025)
Bottom Line: This multicenter, unblinded, randomized superiority trial enrolled 22...
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Free biweekly newsletter for trainees and staff on General Internal Medicine at Sinai Health that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.
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