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Nephro Trial Files

TrialFiles

Free bimonthly newsletter that summarizes the most significant, practice-changing nephrology randomized controlled trials, straight to your inbox.

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Latest Issues

Nephro Trial Files: Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN, AKI After Surgery, and Semaglutide in T2DM

Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN

Fakhouri F et al. NEJM (December 2025)

Bottom Line: This phase 3, double-blind, placebo-controlled trial evaluated the efficacy and safety of pegcetacoplan in 124 ado...

4 months ago
3

Nephro Trial Files Throwback Thursday: Diuretics in Acute Decompensated HF, Postdilution Online Hemodiafiltration, and Chloride-Liberal vs. Restrictive IV Fluids in the ICU

Diuretic Strategies in Patients with Acute Decompensated Heart Failure

Felker GM et al. NEJM (March 2011)

Bottom Line: This was a randomized controlled trial comparing diuretic strategies in 308 patients hospitalized with acute decomp...

5 months ago

Nephro Trial Files: Conservative Dialysis in Dialysis-Requiring AKI, Pravastatin in ADPKD, and Baxdrostat in Uncontrolled and Resistant Hypertension

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury (LIBERATE-D)

Liu KD et al. JAMA (November 2025)

Bottom Line: This multicenter, unblinded, randomized superiority trial enrolled 22...

6 months ago

Nephro Trial Files Throwback Thursday: Simvastatin + Ezetimibe in CKD, Rituximab vs. Cyclophosphamide for ANCA-Associated Vasculitis, and Frequent Hemodialysis

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection)

Baigent C et al. The Lancet (June 2011)

Bottom Line: This was a randomized, double-b...

7 months ago
1

Nephro Trial Files: MMF vs. Cyclophosphamide in Lupus Nephritis, IVIG in Chronic Active AMR, and Felzartamab for IgAN

Mycophenolate Mofetil versus Cyclophosphamide for Initial Therapy in Childhood-Onset Proliferative Lupus Nephritis

Wang Y et al. Journal (September 2025)

Bottom Line: This prospective, multicenter, randomized trial evaluated the effic...

8 months ago
1

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  • TrialFiles

    Free biweekly newsletter for trainees and staff on General Internal Medicine at Sinai Health that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.

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