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Recursive Adaptation

Nicholas Reville, Eli Spector
Tens of paid subscribers

Strategic science and policy for mental health and addiction. Completely free.

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Substack
PricingOnly free issuesPublishesWeekly
Issues99Founded3 years agoLast Issue11 days ago
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Latest Issues

Announcing a major 1,200 person trial of a GLP-1 for addiction recovery and recidivism

I am very pleased to announce that CASPR and Allegheny County DHS will soon be launching a 1,200 person randomized controlled trial of semaglutide for individuals with AUD or OUD and high risk of incarceration, in addiction to existing care...

11 days ago
24
1

PBS Newshour coverage of CASPR’s GLP-1 for addiction pilot programs

Two years ago, I reached out to the Director of Research at Caron Treatment Centers after seeing the results of the Phase 1/2 trial they had run with Sue Grigson and Scott Bunce. I was connected to Dr. Steve Klein at Caron and we decided to...

13 days ago
14

Making a non-opioid painkiller available to everyone would save Medicare and Medicaid $14.9B and prevent hundreds of thousands of new addictions

The role that Purdue pharma and the Sacklers played in the opioid crisis, lying to and manipulating both doctors and regulatory agencies, has been well-documented. These were profound failures of both industry and government. But at the cor...

4 months ago
15

Addiction is like an iceberg: most of the harms are below the surface

Even with all the attention that addiction receives in press and culture, I still believe that the scale of the social harms is under-appreciated. As devastating as addiction is for the people who have a substance use disorder, most of the...

5 months ago
25

How can government drive more medication development for addiction? Our work in DC.

Why are there so few approved medications for addiction? 48.4 million Americans have a substance use disorder, making it one of the most common disease areas in medicine. And 37.8M smoke cigarettes. These addictions drive more deaths and di...

5 months ago
17

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  • Nicholas Reville

    Co-founder and Executive Director of the Center for Addiction Science, Policy, and Research (CASPR). See caspr.org

  • Eli Spector

    Policy Lead

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