Reletter
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SPC is a home for the most talented founders and technologists exploring what's next. Our members turn the chaos of possibility into the clarity of conviction.

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Substack
PricingOnly free issuesPublishesWeekly
Issues204Founded9 months agoLast Issue17 days ago
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blog.southparkcommons.com
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Latest Issues

September 2026 Update

This week, we kicked off our latest Founder Fellowship cohort. It capped a month that brought in new raises across the portfolio, a talk with Waymo's co-CEO in SF on what it takes to put AI on the road, and more than 100 members and alumni...

17 days ago
14

On Building in Uncertainty, and Future of AI Safety

How close are we to AGI, and what happens when AI systems stop behaving the way we expect?

Srinivas Narayanan, former CTO of B2B Engineering at OpenAI and former VP of Engineering at Facebook, joins South Park Commons Partner Prateek Mehta...

a month ago
1

The Case for Talent Density in -1 to 0

“In [research], if you know what you are doing, you should not be doing it. In engineering, if you do not know what you are doing, you should not be doing it.” - Richard Hamming

Going from -1 to 0 isn’t an engineering problem. The notion...

a month ago
10
1

From Early Cancer Detection to the “Everything Test”

What if one blood test could detect hundreds or even thousands of diseases?

Guardant Health CEO Helmy Eltoukhy joins South Park Commons Partner Mark Jacobstein to explain how that vision could become possible.

They trace Guardant’...

2 months ago

What is -1 to 0?

If you have ever discovered a word that describes something you knew but couldn’t express, you know how useful a name can be. It makes a thing more understandable, more tractable. It helps you understand why you might do something and why i...

2 months ago
40
2

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  • South Park Commons
  • Ruchi Sanghvi
  • Aditya Agarwal
  • Prateek Mehta
  • Ryan Atkins
  • Gopal Raman
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