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The Hard Thing

Anna Marie Wagner, Christina Agapakis

Musings about how sh!t gets done.

Platform
Substack
PricingOnly free issuesPublishesWeekly
Issues10SubscribersRead thehardthing.substack.com

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Latest Issues

Recent posts by this newsletter. Browse the email archive.

Hard Thing #7: The BS Umbrella

I recently had a VC describe the Founder/CEO job to me as the “bullsh!t umbrella” - the job is to prevent the BS from reaching the rest of the team.

6 months ago
4
1

Hard Thing #6.2: Hundreds of daily decisions

A fun thing to do with young kids (or students in an intro to CS class) is to ask them to explain how to do simple tasks in the excruciating detail required to actually do them.

6 months ago
9
0

Hard Thing #6.1: Taste All the Way Down

Oscillator and The Hard Thing are blogs by people who have spent many years thinking together about the applications and implications of new technologies in the business of biology. We’re teaming up for a series of posts about AI, biotech, ...

7 months ago
12
3

LMGTFY: A primer on therapeutics R&D

Biotech is the WORST industry for jargon - it reinforces siloes and makes outsiders feel unwelcome...

10 months ago
12
2

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Authors

The writers behind this newsletter.

  • Anna Marie Wagner

    Trying to set a good example for my kids: working hard on problems worth solving.

  • Christina Agapakis

    Bio/tech

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