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Latest Issues

Daraxonrasib Is FDA-Approved: Both Good News and Bad News

Daraxonrasib is an oral RAS(ON) multi-selective, non-covalent inhibitor. In RASolute 302, the product was tested in the second-line setting of patients with metastatic pancreatic cancer, with a median survival gain from 6.7 to 13.2 months....

11 days ago
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Beyond Cross-Trial Comparisons: What Digitized Survival Curves Can Really Tell Us

In today’s guest post, it’s my great pleasure to welcome Yago Garitaonaindia and Marco Donia. The power of reconstructed datasets from published curves cannot be overstated. In a series of three peer-reviewed 2026 publications, they demonst...

a month ago
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Sham Controls and Tumor Treating Fields: Does the Ethical Argument Hold?

Today, we are covering our new work just published in The European Journal of Cancer, entitled “Tumor treating fields: Will the evidence gap ever be filled?”. We thank our co-authors Sruthi Ranganathan, , and Alessandro Hammond!


##...

2 months ago
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EMA and FDA Advocate Removing Amgen’s Drug from the Market: How Unblinded Personnel Manipulated the ADVOCATE Trial

It’s my pleasure to welcome back Sahar Van Waalwijk, who covers an important topic following an unusual development. Enjoy! Timothée


Imagine a wine competition. Judges taste wines from unlabelled bottles and score them without knowi...

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Additional Insights Into Early Daraxonrasib Data

Daraxonrasib is making headlines. A few weeks ago, a press release reported positive phase 3 results from the RASolute 302 trial in second-line metastatic pancreatic cancer, with particular emphasis on a secondary endpoint: overall survival...

4 months ago
23
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Authors

The writers behind this newsletter.

  • Timothée Olivier

    Swiss oncologist at Geneva University Hospital. Research on trial methodology, health policy, and critical appraisal. I joined Vinay Prasad’s research lab in November 2021. Geneva Ethics Committee. Co-EiC ESMO Rare Cancers. No COI. Views mine.

  • Sahar van Waalwijk

    Pharmacist Medicine & Society (PharmD-PhD), National Funder’s Committee for Evaluation of Specialised Medicines and Companion Diagnostics, CZ. Associate Professor of Medical Oncology, focused on Access to Medicines, LUMC, NL

  • Christopher Rios

    UCSF medical student, Harvard alum. Before med school, I worked in gene-editing research and industry-academic collaborations. Now focused on high-value care and healthcare policy. How do we pay for increasingly expensive therapies and innovations?

  • Marco Donia

    Clinician-Scientist, Oncologist, Professor of Immuno-Oncology National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark

  • Yago Garitaonaindia

    Medical Oncologist and Translational Researcher, National Center for Cancer Immune Therapy, CCIT-DK, Copenhagen University Hospital, DK.

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