Zendudest’s Substack
ZendudestMy personal Substack
| Platform |  | Pricing | Only free issues | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 50 | Founded | a year ago | Last Issue | 3 days ago |
| Active | |||||
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zendudest.substack.comLatest Issues
What's up with Ibogaine?
”In the Gabonese night there is an initiatory world that never sleeps. It is the world of the Bwiti”
I’m sure anyone (well at least most of y’all) knows about ibogaine. If not, read the link above.
I returned late last night from a marvel...
AI meets Drug Discovery: Part Deux
In the first part of this series, I described the generic drug discovery pipeline and showed where AI might be useful (or useless). A particular area I would like to highlight here is the “PROTEIN ISOFORM PROBLEM”
Here’s the issue: a sing...
AI will 'solve' drug discovery--right?
I’ve been asked to provide my (unvarnished) thoughts on AI and drug discovery in light of the recent mega-raise of $2.1 Billion USD for Isomorphic Labs. This will, perhaps, be a multi-part collection of my ‘thoughts’.
Below is a standard d...
Are (professional) investors really flocking to psychedelics?
There has been an undercurrent of excitement among psychedelic researchers with the recent executive order to promote research and development of psychedelics and other psychoactive compounds (e.g. MDMA, ibogaine, methylone).
Given this,...
Psychedelics = SSRI's!?
There was quite a kerfuffle on twitter/X regarding this recent paper:
and here’s the data:
Here I highlight my generic concerns with antidepressant drug trials (especially for Treatment Resistant Depression; TRD):
- Placebo responses...
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