Zendudest’s Substack
ZendudestMy personal Substack
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 61 | Founded | a year ago | Last Issue | 19 days ago |
| Active | |||||
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zendudest.substack.comLatest Issues
How anatomy illuminates psychedelic drug actions
I’ve been re-examining a cool paper we recently published (OPEN ACCESS!!) on mice (available at JAX) which express a variety of 5-HT2A receptor constructs useful for many types of studies devoted to understanding how psychedelic drugs work...
What keeps me awake at night regarding psychedelics as approved medications
And it’s not pretty…..
THE THERAPEUTIC EFFECTS ARE NOT NECESSARILY SUSTAINED AND MAY REQUIRE MULTIPLE OR BOOSTING DOSES; SERIOUS SIDE-EFFECTS ARE COMMON WITH SOME PSYCHEDELICS
- Recently reported high incidence of ‘adverse effect...
How to succeed in translational neuroscience
Do not-doing (as Dogen would say)
As many of you know I’m a long-time (40+ years!) and, frankly, a novice Zen student. A few years ago I attended a sesshin (7-day silent retreat) at Great Vow and received the following instruction from a t...
From yeast to humans
In the early 1990’s my lab was devoted to understanding how clozapine achieved it’s remarkable efficacy in treatment-resistant schizophrenia and I was fortunate enough to be recruited to CWRU by Herbert Yale Meltzer (don’t you love his midd...
The joys of being a CRO for the NIH: Part 2
So to continue…by virtue of what I now recognize as a grand cosmic joke my lab was fortunate enough to obtain our FIRST NIH CONTRACT in 1998. Per his promise my former chair—the amazing Richard Hanson (may his memory be a blessing)—gave me...
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