Where Theory Meets Practice
Brooks Leitner, MD, PhDShort essays bridging science-based theories with real-world applications in startups and society, tailored for scientists, entrepreneurs, and investors in health and biotech.
| Platform |  | Pricing | Only free issues |
|---|---|---|---|
| Publishes | Weekly | Issues | 21 |
| Subscribers | Read | brooksleitner.substack.com |
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Latest Issues
Recent posts by this newsletter. Browse the email archive.
Biological Age: The Science and History Behind the Biomarker of Health
This article is a deep dive into the science and history of the measurement of Biological Age. After a brief intro, check out the deep dive informed by DeepResearch.
Clinical Phenotyping to Increase Patient Benefit in CNS Clinical Trials: Insights from TREM2 Trials for Alzheimer’s
I discuss recent developments in the pharmacological treatment of Alzheimer’s and posit that to meaningfully improve people’s lives we need to pay more attention to the patient. Translational phenotyping is a strategy to both increase likel...
To Improve, You Need Randomness: Evolution is the Positive Selection of Randomness Over Time
This article is a bit more philosophical than most of my posts. But hopefully it changes how you think about improvement. I draw on principles of evolutionary theory and complex adaptive systems based on a conversation of the mechanism of p...
The Dose Maketh the Poison: Where Are Individualized Dosing Strategies?
Photo by Raghav Bhasin on Unsplash
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Authors
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Investor blending theory and evidence-based insights to explore a healthier future. Writings on frontier technologies and concepts about advancing human health in today’s environment.
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