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The Physiology of Scale

Brooks Leitner, MD, PhD

From molecules to society—the science and business of translating human physiology at scale.

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Latest Issues

Health and Longevity Have Always Been About Human Performance

In my 2017 applications to MD/PhD Programs I wrote:
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Why Would an MD-PhD Start a Company?

I heard some version of this question in nearly every conversation I had with investors while raising our pre-seed round. Happens with numerous clinicians, trainees, and scientists I speak with regularly as well.

Usually it came right afte...

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"Bench to Bedside" Needs an Update. Here's What Comes Next.

I interviewed for MD/PhD programs a decade ago. The bench to bedside narrative was really compelling, and sounded like the perfect blend of theoretical physiology and problem solving in the lab, with the practical application to improve hum...

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The Germ Theory of Fitness

In 1847, a Hungarian physician named Ignaz Semmelweis made an observation that should have changed medicine overnight. Doctors who washed their hands before delivering babies reduced maternal deaths from puerperal fever dramatically. The be...

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The Dataset Imperative to Guide AI-Driven Healthspan and Performance

I participated this weekend as a mentor at Yale’s Healthcare Hackathon. More than 220 participants (47% Yale-affiliated, spanning CT, NYC, CA, and Brazil) proposed over 50 health-focused ventures.

Nearly half involved using large language...

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  • Brooks Leitner, MD, PhD

    Blending theory and evidence-based insights to explore a healthier future. Writings about advancing human health in today’s environment.

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