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Compounding Leadership

Nick Makris

25+ years of Life Sciences boardroom experience distilled into practical Leadership playbooks. No fluff. No corporate speak. Just the hard truths that actually move the needle.

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Substack
PricingOnly free issuesPublishesWeekly
Issues70Founded2 years agoLast Issue8 days ago
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Latest Issues

If You Can’t Articulate Intent, AI Won’t Save You

❇️ Master Commander’s Intent to lead humans and AI. Learn how clarity, purpose, and boundaries turn leaders into architects of outcomes in a hybrid workforce.


Photo by Rommel Davila on Unsplash


I Learned Commander’s Inte...

8 days ago
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Is the HiPPO in the room?

❇️ The HiPPO is in the room. Yes, senior voices carry weight. Momentum can shift from discussion to compliance fast. This is how to keep ideas alive and decisions informed.


A familiar moment

The room went silent.

In my care...

22 days ago
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Leadership in an AI World: Prepared or Replaced?

❇️ AI won't replace leaders, but leaders using AI will replace those who don't. This is how to stop treating AI like a shiny new toy and start using it to amplify your decision-making. Are you ready?

Photo by Nahrizul Kadri on Unsplash

*...

a month ago
5

Stop Pretending You Know More Than You Do

❇️ Most leaders judge decisions by outcomes. Learn how to think in probabilities, treat choices like bets, and separate signal from noise to make smarter, repeatable decisions.

Photo by Michał Parzuchowski on Unsplash


Heads I W...

2 months ago
20
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You Don’t Have a Strategy. You Have a Very Long To-Do List.

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Help !

“Great, you’re here.”

I walked into the meeting room to a flurry of act...

2 months ago
6

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  • Nick Makris

    25+ years of Life Sciences boardroom experience ✦ Writing the Leadership playbooks they don't teach in business school ✦ Drawing on real scar tissue and the wisdom of giants

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