When what we don’t know is more important than what we do. Wrestling with conflict and controversy in science, medicine, health and nutrition.
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 52 | Founded | 2 years ago | Last Issue | 13 days ago |
| Active | |||||
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uncertaintyprinciples.substack.comLatest Issues
Discussing Controversy in Medical Science: Air It Out or Sweep It Under the Rug?
“Ignoring difficulties is a poor way of solving them,” Raymond Greene wrote in 1953. Not everyone in medicine would agree.
We recognize the existence of a medical pedagogy devoted to turning out practical doctors, trained to go into action...
The Black Hole at the Galactic Core of Obesity and GLP-1 Drug Science
A new Endocrine Society “Scientific Statement” puts the brain at the center of obesity and GLP-1 action—but ignores the means by which the brain directly regulates fat storage.
The answers to today’s quiz may seem obvious. The questions ma...
Is Sugar Toxic? Can It Cause Cancer? CHD? Frailty? Dementia?
14 analyses in the last 2 years add to the evidence that it is, and it might. The Washington Post begs to disagree.
Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic...
Lowering LDL: Surely, a “Heart-Healthy” Diet Is Worth the Effort. Isn’t it?
Assuming (uncharacteristically) that the American heart Association’s diet-heart thinking is right, what do we gain by eating to lower our LDL?
Although there are undoubtedly persons who would choose to participate in a lifelong regimen of...
Blah Health Journalism: Meat, Sauerkraut and Politics Edition.
What's it take to get the traditional media (or at least The New York Times) to understand the appeal of unconventional diets?
Question of the day: Why do people eat fad diets?
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Authors
The writers behind this newsletter.
Investigative science and health journalist, author of Rethinking Diabetes (2024), The Case for Keto (2020), The Case Against Sugar (2016), Why We Get Fat (2011), and Good Calories, Bad Calories (2007), published as The Diet Delusion in the UK.
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