When what we don’t know is more important than what we do. Wrestling with conflict and controversy in science, medicine, health and nutrition.
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 54 | Founded | 2 years ago | Last Issue | 6 days ago |
| Active | |||||
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uncertaintyprinciples.substack.comLatest Issues
Is Food Really Medicine? (If So, Which Foods?)
What matters more, what we eat or what we don’t? And why does keto keep confounding attempts to define healthy eating?
The food we eat is making us sick. In the United States and around the world, diet has become the leading cause of illne...
Sugars in Evolution and Huberman’s Protocols
When the “remarkable” efficacy of a ketogenic diet gets in the way of a good story.
Progress report on the last 30 years of work on the relationship between diet and chronic disease:
Discussing Controversy in Medical Science: Air It Out or Sweep It Under the Rug?
“Ignoring difficulties is a poor way of solving them,” Raymond Greene wrote in 1953. Not everyone in medicine would agree.
We recognize the existence of a medical pedagogy devoted to turning out practical doctors, trained to go into action...
The Black Hole at the Galactic Core of Obesity and GLP-1 Drug Science
A new Endocrine Society “Scientific Statement” puts the brain at the center of obesity and GLP-1 action—but ignores the means by which the brain directly regulates fat storage.
The answers to today’s quiz may seem obvious. The questions ma...
Is Sugar Toxic? Can It Cause Cancer? CHD? Frailty? Dementia?
14 analyses in the last 2 years add to the evidence that it is, and it might. The Washington Post begs to disagree.
Excess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic...
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Authors
The writers behind this newsletter.
Investigative science and health journalist, author of Rethinking Diabetes (2024), The Case for Keto (2020), The Case Against Sugar (2016), Why We Get Fat (2011), and Good Calories, Bad Calories (2007), published as The Diet Delusion in the UK.
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