When what we don’t know is more important than what we do. Wrestling with conflict and controversy in science, medicine, health and nutrition.
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 42 | Founded | 2 years ago | Last Issue | 9 days ago |
| Active | |||||
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uncertaintyprinciples.substack.comLatest Issues
Diet or Drugs, Calories or Carbohydrates? Longevity medicine comes for your dog.
Beneath the headlines, the carbohydrate-insulin model is now hiding in plain sight.
Let’s talk about Chilly, the endearingly cute animal posing heroically on our front stoop in the photo below.
The History of a Very Bad Idea: Understanding Obesity Before Calories In and Out.
How would you discuss the cause of obesity if you weren't burdened by the notion that it's an energy balance disorder?
I’ve been mired in the history of obesity science lately, so this week’s newsletter is a variation on what medical stude...
Brain Health vs. Heart Health? Is Eating Meat Good for Cognition but Bad for Our Arteries?
A new Swedish study on meat consumption and Alzheimer's Disease speaks to the "anti-randomization" problem of nutrition science.
“There is a lack of dietary research into brain health, and our findings suggest that conventional dietary adv...
The "One of Us Stinks" Problem: LDL, the Lipid Hypothesis, the AHA, and Humphrey Bogart
Wouldn't it be nice to think that arguments and evidence can change minds? I wouldn't bet on it.
…in 1943, John Forsythe, then a fledgling actor, had worked out what was considered by all who saw it a clever impersonation of [Humphrey] Bog...
LDL, Saturated Fat, and Heart Disease: Should We Worry?
A tale of two competing paradigms and why I hope my diet isn't killing me.
Ever since the heady days of the Atkins diet in the early 1970s, the cosmic joke about ketogenic diets has been that, regardless of their efficacy for reducing weig...
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Authors
The writers behind this newsletter.
Investigative science and health journalist, author of Rethinking Diabetes (2024), The Case for Keto (2020), The Case Against Sugar (2016), Why We Get Fat (2011), and Good Calories, Bad Calories (2007), published as The Diet Delusion in the UK.
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