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Latest Issues

A Reflection on GLP-1s in the Clinic

I’m not going to talk about the studies that support the use of glucagon-like peptide-1 (GLP-1) receptor agonists for weight loss or DM. Nor will I attempt to wax poetic about their effect on our society. A journalistic cottage industry alr...

2 days ago
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The COVID Vaccine for Pregnant Women

Last week, Vinay Prasad posted a “Frequently Asked Questions” article. I was tempted to respond with my answers to the questions that Vinay is frequently asked. David Rind acted on my temptation and wrote about one of the questions that Vin...

3 days ago
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This Fortnight in Medicine XXXV

Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy

  • The Hubris of Screening for Disease — Again

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Im...

4 days ago
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When a Secondary Endpoint Is the Story of a Trial

The Study of the Week column has two main goals: one is to inform you about a recent advance in medicine, and the other is to teach a lesson in critical appraisal.

Critical appraisal teaching is the reason to study the POET II trial.

It...

6 days ago
105
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Private equity in primary care: true villain or another corporate boss?

Although I am generally an optimist, I am pessimistic about the entry of private equity (PE) into healthcare, particularly primary care. Although I could imagine a world in which PE does some good—making money by reducing waste in medical c...

8 days ago
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Authors

The writers behind this newsletter.

  • John Mandrola

    Heart rhythm doc, writer/podcaster for @Medscape, learner, cyclist, married to an #HPM doctor. #MedicalConservative. The more you see, the harder medicine gets

  • Vinay Prasad MD MPH

    Hematology Oncology Medicine Health Policy Epidemiology Professor

  • Adam Cifu, MD

    Internist, professor, patient. Author: Ending Medical Reversal; Symptom to Diagnosis; Sensible Medicine. Podcasts: S2D & Clinical Excellence.

  • Matthew Allen

    Physical Medicine & Rehabilitation at the University of Washington.

  • Dr. Lucy McBride

    Primary care doctor & bestselling author dispensing fact-based, practical advice that fits your life. Health isn't about having all the answers; it's about asking better questions—of yourself, and of the people responsible for your care.

  • Howard Luks MD

    I'm Howard Luks, MD, a 63-year-old orthopedic surgeon and author of Longevity Simplified. I write about exercise physiology, metabolic health, and the science of aging well.

  • John W. Ayers

    John W. Ayers PhD MA is a Johns Hopkins, Harvard trained computational epidemiologist, known for his work on emerging technologies and public health. www.johnwayers.com

  • Nitin Gogtay, M.D.

    Psychiatrist and author of The Vanishing Children (HarperCollins, 2027). VP of Research & Deputy Medical Director at the American Psychiatric Association. I write Beneath the Diagnosis: on seeing the person the label hides.

  • Mary C Meyer
  • Jeff Krauss, MD

    Jeff is the Chief Medical Officer at Hinge Health. He’s an affiliated professor at Stanford and a part-time Physical Medicine & Rehabilitation physician at the VA Palo Alto. Prior to medicine, he was a product manager for 8 years at Oracle and eBay.

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