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Common sense and original thinking in bio-medicine

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Latest Issues

Four Ways to Decrease Overall Mortality

Good medicine is all about careful observation. You’ve probably heard the legend of the medical school professor who teaches his students about the importance of using the five senses as diagnostic tools. In front of the class, he dips a fi...

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When do you need a disease expert and when do you need a data expert?

When do you need a disease expert and when do you need a data expert? I occasionally find a reader in these pages wondering why we didn’t ask a mental health expert or infectious expert to opine on some topic, which John, Adam and I wrote a...

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This Fortnight in Medicine XXX

Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial

John Mandrola: I am torn on the PolyPill concept

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Is Universal Testing for Lp(a) Warranted?

There has been lots of commentary on the 2026 Lipid guidelines. , , and even did an “emergency podcast” on the topic which broke all download records for us. One thing that I think has been covered less is the recommendation for Lp(a) test...

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Can AI tell you who needs an ICD?

Here is something different for the Study of the Week. This week, Joe Marine and Vinay help me sort out a complex AI paper. JMM


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Authors

The writers behind this newsletter.

  • John Mandrola

    Heart rhythm doc, writer/podcaster for @Medscape, learner, cyclist, married to an #HPM doctor. #MedicalConservative. The more you see, the harder medicine gets

  • Vinay Prasad

    Hematology Oncology Medicine Health Policy Epidemiology Professor

  • Adam Cifu, MD

    Internist, professor, patient. Author: Ending Medical Reversal; Symptom to Diagnosis; Sensible Medicine. Podcasts: S2D & Clinical Excellence.

  • Alasdair Munro

    Cutting through the noise on child health, vaccines, and medical evidence. By a working NHS paediatrician and researcher.

  • Andrew J Foy

    Associate Professor of Medicine and Public Health Sciences at Penn State Hershey Medical Center and College of Medicine

  • Anthony DiGiorgio, DO, MHA

    Neurosurgeon & health policy wonk.

  • Howard Bauchner

    Howard is the former EIC of JAMA and JAMA Network. He renamed the Archives Journals, launched 4 journals, JAMA Oncology, Cardiology, Network Open, and Health Forum and social media accounts grew from about 15,000 to well over 1,000,000.

  • Paul Windisch, MD

    Physician Scientist in Radiation Oncology with an interest for software.

  • George M Rodgers

    I am an academic hematologist focusing on benign blood disorders, especially bleeding and clotting disorders.

  • Ming Y Lim

    Dr. Ming Y. Lim is a Professor in the Division of Hematology and Hematologic Malignancies at the University of Utah.

  • Michael Auerbach

    Physician, interested in your work

  • Thomas DeLoughery

    Hematologist

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