Greg Katz, MD
Understanding what actually matters in medicine
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 326 | Founded | 6 years ago | Last Issue | 14 days ago |
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gregorykatz.substack.comLatest Issues
The Lp(a) Drug Failed. Why Were We So Sure It Would Work?
The news that a Novartis drug for lowering Lp(a) failed in a clinical trial is a bombshell.
Pelacarsen is a drug that lowers Lp(a) by roughly 80%. But in the first large trial designed to find out whether lowering Lp(a) actually prevents c...
The Most Misused Test in Medicine
The coronary artery calcium score (CAC) is probably the most misused medical test today.
This week is the annual European Society of Cardiology (ESC) Conference, where a lot of new research is presented, and one of the most important and i...
Does inflammation cause heart disease?
Inflammation pretty clearly seems to be involved in heart disease.
Look at the arteries of people with heart disease under a microscope, you’ll find inflammation.
People who have chronic inflammatory diseases like lupus, rheumatoid arthr...
Medicine’s “You Can Just Do Things” era
Two things happened in medicine recently that seem at first glance to have almost nothing in common.
The first item is the news about Kalshi starting to open up prediction markets for clinical trials.
The second is the liberalization of F...
A health book I actually recommend
Some people come to the doctor when they don’t feel well and the diagnosis is totally clear based on a few questions about their symptoms and a cursory exam with testing.
But most people aren’t simple like that - their lives are complicate...
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Authors
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Cardiologist and internal medicine APD at NYU. Co-host of Beyond Journal Club with NEJM and CoreIM
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