Janet Maendel DO(EUR), DNM
Janet Maendel DO(EU)Integrative oncology clinician specializing in metabolic terrain and immune-based cancer care. Writing to replace fear with clarity and strategy.
| Platform |  | Pricing | Only free issues | Publishes | Daily |
|---|---|---|---|---|---|
| Issues | 33 | Founded | 5 months ago | Last Issue | 9 days ago |
| Active | |||||
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janetmaendel.substack.comLatest Issues
The Engine of Persistence: Why Mitochondrial Integrity is the Real Checkpoint
In the world of immuno-oncology, we are obsessed with activation. But activation without persistence - the ability to stay in the fight long enough to actually achieve control - is often where the strategy fails. To win, we have to look pa...
The Resource War: Why You Can’t Fight a War on an Empty Stomach
Photo by Egor Myznik on Unsplash
We have spent decades trying to “awaken” the immune system to recognize cancer, but we’ve ignored the most basic rule of engagement: logistics. You can have the most elite, highly trained T-cell army in the...
Beyond the On-Switch: The Tactical Intelligence of Double Loaded Dendritic Cell Therapy (IDCT)
Photo by Ashutosh Dave on Unsplash
In the current landscape of Immuno-Oncology, we are often sold the idea that simply "unleashing" the immune system is enough. But activation isn't a strategy—it’s just a spark.
IDCT: Restoring the...
The Liver–Immune Axis: How Hepatic Function Determines Immune Response
Photo by julien Tromeur on Unsplash
The liver is often described as a metabolic or detoxification organ, but clinically, it functions just as much as an immune organ.
It sits at a critical intersection - receiving blood from the gut, proc...
Tumor Visibility in Immuno-Oncology: The Problem of Recognition
Photo by Edi Libedinsky on Unsplash
For the immune system to respond appropriately, it must be able to identify what is abnormal. This process depends on antigen presentation - tumor derived proteins that are processed and presented to the...
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The writers behind this newsletter.
Janet Maendel DO(EUR) is an integrative oncology clinician whose work centers on immunometabolism & metabolic approaches to cancer care. She explores clinical reasoning, data interpretation, and the biological context beneath diagnosis.
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