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Longevity Lifehacks

Hundreds of paid subscribers

Exploring and explaining the current research on longevity and healthy aging. The focus is on real solutions, along with some out-of-the-box thinking, as I experiment with turning back the biological clock.

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Substack
PricingFreemiumPublishesWeekly
Issues113Founded4 years agoLast Issue12 days ago
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Latest Issues

Gut Barrier Lifehacks: The Map

Hi everyone —
Longevity Lifehacks is where I’ve put my notes, thoughts, and solutions based on new research studies related to healthspan and longevity. After 3+ years, it’s become hard for me to keep track of everything — how the interv...

12 days ago
15

Immune checkpoints, microglia, and healthy brain aging

Here’s an interesting new study in Science Advances: Targeting glial PD-1/PD-L1 restores microglial homeostasis and reduces neuronal hyperactivity in an Alzheimer’s disease model (Park et al. 2026)

The researchers looked at the effect of b...

18 days ago
9
3

Cellular Senescence Lifehacks: The Map

Hi everyone — Longevity Lifehacks is where I put my notes, thoughts, and solutions based on new research in healthspan and longevity.

After 3+ years, it’s become hard for me to keep track of everything — how the interventions tie together,...

22 days ago
3
1

Alzheimer’s Lifehacks: The Map

Hi everyone -
Longevity Lifehacks is where I put my notes, thoughts, and solutions that are based on new research in the fields of healthspan and longevity.

After 3+ years, it’s become hard for me to keep track of everything - how the...

a month ago
14

Fibronectin, blood-brain barrier, and brain health

For several decades, Alzheimer’s research has focused on preventing the buildup of amyloid-beta plaque in the brain. Amyloid beta is a peptide fragment of a larger glycoprotein called the amyloid precursor protein (APP), which is involved i...

a month ago
19
1

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  • Longevity Lifehacks

    Exploring the science of healthspan and longevity by diving into the interesting studies and looking at how they can be applied. Debbie Moon is an author and founder of Genetic Lifehacks. www.GeneticLifehacks.com.

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