Metabolic treatment of cancer and other disorders
| Platform |  | Pricing | Only free issues | Publishes | Daily |
|---|---|---|---|---|---|
| Issues | 51 | Founded | a year ago | Last Issue | 5 days ago |
| Active | |||||
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paulmarik.substack.comLatest Issues
Metformin: The Most Important Repurposed Drug in Cancer Care
Metformin exerts multiple anticancer effects, mainly by reprogramming tumor and host metabolism and converging on mTOR and related growth/survival pathways. Numerous trials have shown that metformin, routinely used to treat diabetes, inhibi...
Repurposed Drugs and Nutraceuticals That Improve Systemic Immunity and the Tumor Microenvironment
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Cancer progression is not simply a problem of uncontrolled cell growth. It is also a failure of immune surveillance. In a healthy host, abnormal cells are detected and eliminated by natural killer cells, cytotoxic CD8+ T cell...
Perioperative Repurposed Drugs To Reduce Metastases
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Peri-operative medications that reduce metastatic risk should be regarded as standard of care. With a simple, low-cost intervention, we can prevent avoidable deaths. Choosing not to offer this evidence-based treatment is, in...
Cancer, Warburg and Fatty Acid Oxidation: A Clearer Understanding
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The recent two-part series on fatty acid oxidation in cancer generated considerable confusion and many questions. Dr. Thomas Seyfried reached out to me specifically to help clarify this issue. The observation that some cancer...
What COVID Taught Me About Medicine
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This post steps away from my usual focus on cancer and metabolic disease and instead shares a deeply personal story: how I was pushed out of clinical medicine. COVID forced me to confront just how profoundly—and, at times, de...
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Authors
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The treatment of Cancer and Metabolic diseases using diet, repurposed pharmaceuticals, and targeted nutraceuticals.
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