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Stop and Think

John Mandrola

A skeptical but not cynical view of scientific evidence

Platform
Substack
PricingFreemiumPublishesWeekly
Issues67SubscribersRead johnmandrola.substack.com

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#46
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Latest Issues

Recent posts by this newsletter. Browse the email archive.

Older cardiology trials were often hugely positive. Newer cardiology trials not so much

I wrote yesterday over at Sensible Medicine about the RALES (circa 1999) trial of spironolactone vs placebo in patients with heart failure. Patients treated in the spironolactone arm had an 11% lower rate of death. The number needed to save...

a month ago
31
15

Links to My Recent Writing and Speaking

#### Statin Use and the New Risk Calculator

2 months ago
41
1

I Might Have Been Wrong About Pulsed Field Ablation for Atrial Fibrillation

Hi everyone. I’ve been stunned about all the new subscribers. I am not sure what happened, but thank you for signing up.

2 months ago
72
15

How do Dubious Norms Get Established?

One area continues to dominate my field of cardiology. It is the search for and treatment of ischemic heart disease. Coronary heart disease dominates the minds of patients and doctors alike.

3 months ago
81
25

Authors

The writers behind this newsletter.

  • John Mandrola

    Heart rhythm doc, writer/podcaster for @Medscape, learner, cyclist, married to an #HPM doctor. #MedicalConservative. The more you see, the harder medicine gets

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