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Stop and Think

John Mandrola
Hundreds of paid subscribers

A skeptical but not cynical view of scientific evidence

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Substack
PricingFreemiumPublishesWeekly
Issues86Founded5 years agoLast Issuea month ago
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Latest Issues

Body Scanning and Philosophy

Journalist Christina Farr hosted this interview/podcast with three doctors regarding the idea of preventive total body imaging to extend life. It’s a good discussion. My friend Venk Murthy particularly excels.

The concept is enticing: man...

a month ago
92
25

Just Another Summer Update

The popular economist Tyler Cowen advises that in the era of AI, writing has decreased in value. Increased in value are things that AI cannot do: be with people in person. I’ve done a lot of that recently, not so much because TC recommends...

a month ago
66
12

Industry vs Non-Industry Funding for Science

Look at this recent post on X:

Dr Holly Morgan is cardiologist and researcher in the UK and was an author on one of the best cardiology trials of our time—the REVIVED BCIS2 trial.

Dr Sunil Rao is a cardiologist and researcher who has pu...

5 months ago
63
16

Some Year End Things and A Pro-Tip

Here’s another update of things I’ve worked on.

My year end review of top cardiovascular stories is up over at TheHeart.org | Medscape Cardiology. We learnt quite a bit in 2025.

  • Two trials suggested less-is-more when it comes to com...
7 months ago
75
11

What I believe in Medicine

Dr. Bryan Vartabedian has a great post on 75 things he believes about medicine. Do read it. There are many gems. Bryan and I started our careers at about the same time.

Stop and Think is a reader-supported publication. To receive new post...

8 months ago
151
21

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  • John Mandrola

    Heart rhythm doc, writer/podcaster for @Medscape, learner, cyclist, married to an #HPM doctor. #MedicalConservative. The more you see, the harder medicine gets

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