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Stop and Think

John Mandrola
Hundreds of paid subscribers

A skeptical but not cynical view of scientific evidence

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Substack
PricingFreemiumPublishesWeekly
Issues88Founded5 years agoLast Issue9 days ago
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Artwork for Stop and Think

Latest Issues

Good Questions that I was Asked at the Cardiology Society of Australia and New Zealand Meeting

I’m in Sydney at the CSANZ meeting. Here are questions I was asked yesterday during a session for cardiology fellows:

What has cardiology gotten spectacularly right, and spectacularly wrong, over the past 30 years?

Spectacular: The treat...

9 days ago
59
8

Evidence is what separates doctors from palm readers but there are caveats

Andrew Foy had an important post last week over at Sensible Medicine. He told the story of spironolactone in heart failure. I often cite the RALES trial of spironolactone vs placebo as one cardiology’s biggest effect sizes. The absolute red...

20 days ago
84
10

Body Scanning and Philosophy

Journalist Christina Farr hosted this interview/podcast with three doctors regarding the idea of preventive total body imaging to extend life. It’s a good discussion. My friend Venk Murthy particularly excels.

The concept is enticing: man...

a month ago
93
27

Just Another Summer Update

The popular economist Tyler Cowen advises that in the era of AI, writing has decreased in value. Increased in value are things that AI cannot do: be with people in person. I’ve done a lot of that recently, not so much because TC recommends...

2 months ago
66
12

Industry vs Non-Industry Funding for Science

Look at this recent post on X:

Dr Holly Morgan is cardiologist and researcher in the UK and was an author on one of the best cardiology trials of our time—the REVIVED BCIS2 trial.

Dr Sunil Rao is a cardiologist and researcher who has pu...

6 months ago
63
16

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  • John Mandrola

    Heart rhythm doc, writer/podcaster for @Medscape, learner, cyclist, married to an #HPM doctor. #MedicalConservative. The more you see, the harder medicine gets

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