Stop and Think
John MandrolaA skeptical but not cynical view of scientific evidence
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 69 | Subscribers | Read | johnmandrola.substack.com |
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Latest Issues
Recent posts by this newsletter. Browse the email archive.
Thank You
Just a short note to say thank you to those who follow this Substack. I am grateful to have readers.
Electrophysiology is on the brink of a possible disaster
The OPTION trial compared two strategies to reduce stroke and bleeding after catheter ablation of atrial fibrillation. The current strategy is to continue an anticoagulant medication. The alternative tested in OPTION is to implant a left at...
Older cardiology trials were often hugely positive. Newer cardiology trials not so much
I wrote yesterday over at Sensible Medicine about the RALES (circa 1999) trial of spironolactone vs placebo in patients with heart failure. Patients treated in the spironolactone arm had an 11% lower rate of death. The number needed to save...
Links to My Recent Writing and Speaking
#### Statin Use and the New Risk Calculator
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Authors
The writers behind this newsletter.
Heart rhythm doc, writer/podcaster for @Medscape, learner, cyclist, married to an #HPM doctor. #MedicalConservative. The more you see, the harder medicine gets
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