Four Fifty One
Jason SteinerLong-form, original work on science, technology, and policy
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 52 | Founded | 4 years ago | Last Issue | a month ago |
| Active | |||||
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biotechbio.substack.comLatest Issues
AI Bio-Risk Land
In 2023, a Harvard/MIT-led team demonstrated an evolutionary selection system for optimizing gene-editing machinery. The system continuously generated variations and directly enriched variants that performed the desired molecular function -...
OpenAI/Hugging Face Hack
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Update 9/15/26 — The initial description of this event discussed in the section below Mimicry is the Mode, Not Intentionality in the original post is unresolved as to whether the RL that individual agents were traine...
Scientific SuperIntelligence
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Eating the World
Superintelligence is all the rage. Technology executives are already claiming that we are in the singularity — or perhaps not. Sam Altman, who has famously said that AGI has a high likelihood of d...
Robust AI for Clinical Programs
This post is a short communication about a new publication I am starting that focuses on agentic analysis of clinical stage biotech and biopharma programs. If you are interested in this topic you can you check it out here:
EmberFinch Resea...
Reading the Machine
Automated Interpretability: A 90-Minute Deep Dive into AI’s Own Mechanics
A recurring theme in AI development is the question of when systems will be able to meaningfully contribute to their own improvement. The recursive self-improvement...
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| Subscribers | Engagement | 66 | Monthly Web Visits | ||
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Authors
The writers behind this newsletter.
I write about the intersection of the biological and computational sciences. Sometimes this borders on the philosophical, sometimes strategic, and sometimes technical.
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