Thinking Psychiatry
Kevin Kennedy, MDThinking critically about evidence and ethics in psychiatry.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 9 | Subscribers | Read | thinkingpsychiatry.substack.com |
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Latest Issues
Recent posts by this newsletter. Browse the email archive.
Questioning the hype for TMS in adolescent depression
In March 2024, the FDA cleared the NeuroStar transcranial magnetic stimulation (TMS) device “as an adjunct for the treatment of Major Depressive Disorder (MDD) in adolescent patients (age 15-21).” This clearance was widely celebrated. A glo...
Losing faith in the SAINT Protocol (Part 2)
A previous post evaluated the first SAINT TMS protocol clinical trial, where I raised concerns about the tiny sample, unusual outcome measures, risk of effective unblinding, and missing data for blinding integrity. I was worried that the hy...
Losing faith in the SAINT protocol (Part 1)
I’ve been reading more TMS trials recently. Today, I’ll focus on the first SAINT protocol RCT published in 2021—probably the single most famous and influential TMS study. A subsequent post will look at the replication RCT just published in ...
Why does Abilify augmentation only work in Pittsburgh?
This may be a particularly nerdy post. But it’s important. Aripiprazole (branded Abilify) augmentation has become a major treatment strategy for difficult-to-treat depression. Two large clinical trials suggest that aripiprazole augmentation...
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Authors
The writers behind this newsletter.
I am an academic psychiatrist trying to improve the quality of evidence in psychiatry. I'm in favor of humility and against hype and bad science. All views my own.
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