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Polypharmacy

Nils Wendel, MD, Kevin Kennedy, MD
Tens of paid subscribers

Rationalist-adjacent musings on psychiatry

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Substack
PricingOnly free issuesPublishesWeekly
Issues45Founded3 years agoLast Issue7 days ago
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Latest Issues

Why I Am Critical of TMS for Depression

This is the first in a series of essays on two major concerns I have with the growing use of transcranial magnetic stimulation (TMS) for depression. The first concern is with TMS research. The second concern is the marketing of TMS. I think...

7 days ago
29
24

Benzodiazepines for PTSD: How Weak Evidence Became Conventional Wisdom

Unless you live under a rock, the consensus in psychiatry is that benzodiazepines are harmful in PTSD and should be avoided at all costs. Beyond the known risks of benzodiazepines, we are told that they are ineffective for core PTSD symptom...

17 days ago
26
5

Is There Any Merit to Antipsychotic Polypharmacy?

Work in psychiatry for ~~long enough~~ any amount of time, really, and you will see patients with schizophrenia on some pretty heavy antipsychotic regimens. Here are a few recent med lists that I’ve seen:

Patient A:

  • Lurasidone 160mg...
24 days ago
27
18

Psychiatrists should not be superstitious pigeons

Photo via Psychology Pictures (from an experiment in which Skinner taught pigeons to play ping pong)

In 1948, the behavioralist B.F. Skinner published “‘Superstition’ in the Pigeon.”1 Skinner devised a contraption where he took starving pi...

a month ago
48
20

Are we treating bipolar II disorder incorrectly?

I’ve been preparing lectures on the treatment and bipolar disorder, but I keep running into the same question: what is the point of bipolar II disorder?

I’m not arguing about the validity of the diagnosis, whether it’s underdiagnosed or ov...

2 months ago
68
32

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Authors

The writers behind this newsletter.

  • Nils Wendel, MD

    Psychiatrist, independently minded to a troublesome degree. Occasionally produces original thoughts worth sharing.

  • Kevin Kennedy, MD

    An academic psychiatrist trying to improve the quality of evidence in psychiatry. I’m pro humility and against hype and bad science. All views my own. “A cynic is a man who knows the price of everything, and the value of nothing.”

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