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Polypharmacy

Nils Wendel, MD, Kevin Kennedy, MD
Tens of paid subscribers

Rationalist-adjacent musings on psychiatry

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Substack
PricingOnly free issuesPublishesWeekly
Issues47Founded3 years agoLast Issue12 days ago
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Latest Issues

Concerns about the Marketing of TMS for Depression

This piece comes from several months reading TMS clinic websites. My critique is not of TMS, but of marketing that has gone too far. While I would prefer to write about clinical trials, I am convinced that this issue requires greater attent...

12 days ago
27
7

How Quickly Do Antipsychotics Work?

Using antipsychotics well is a tricky business. We certainly know that they work, but questions beyond that linger. Is the response that we see within the first handful of days of starting an antipsychotic because of improvements in psychot...

20 days ago
34
1

Why I Am Critical of TMS for Depression

This is the first in a series of essays on two major concerns I have with the growing use of transcranial magnetic stimulation (TMS) for depression. The first concern is with TMS research. The second concern is the marketing of TMS. I think...

a month ago
35
26

Benzodiazepines for PTSD: How Weak Evidence Became Conventional Wisdom

Unless you live under a rock, the consensus in psychiatry is that benzodiazepines are harmful in PTSD and should be avoided at all costs. Beyond the known risks of benzodiazepines, we are told that they are ineffective for core PTSD symptom...

a month ago
29
8

Is There Any Merit to Antipsychotic Polypharmacy?

Work in psychiatry for ~~long enough~~ any amount of time, really, and you will see patients with schizophrenia on some pretty heavy antipsychotic regimens. Here are a few recent med lists that I’ve seen:

Patient A:

  • Lurasidone 160mg...
a month ago
31
18

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Authors

The writers behind this newsletter.

  • Nils Wendel, MD

    Psychiatrist, independently minded to a troublesome degree. Occasionally produces original thoughts worth sharing.

  • Kevin Kennedy, MD

    An academic psychiatrist trying to improve the quality of evidence in psychiatry. I’m pro humility and against hype and bad science. All views my own. “A cynic is a man who knows the price of everything, and the value of nothing.”

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