Polypharmacy
Nils Wendel, MDRationalist-adjacent musings on things we do in psychiatry
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 33 | Founded | 3 years ago | Last Issue | 2 months ago |
| Active | |||||
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polypharmacy.substack.comLatest Issues
Same As It Ever Was
We have new Cobenfy (Xanomeline/Trospium) data, so I have a new analysis.
I’ve been saying that Xanomeline is a very average looking antipsychotic in terms of efficacy, but is incredibly attractive when it comes to side-effects: No EPS, no...
Should All Depressed Patients Be On Adjunctive Mirtazapine?
Over the past couple of decades, a lot of the common psychiatric dogmas around antidepressant prescribing for depression have not held up well.
Shouldn’t we push the dose as high as can be tolerated before declaring treatment failure?...
Yes, Involuntary Commitment Really Is That Complicated
Tewksbury State Hospital Administrative Building, in Tewksbury, MA By John Phelan - Own work, CC BY 3.0
Those of you aware of Psychiatry Substack might be aware of a paper A Danger to Self and Others: Health and Criminal Consequences of In...
Why Are Psychiatry Boards So Useless?
Today I took my psychiatry boards. 425 multiple choice questions. I should feel glad to be done, but what I mostly feel is annoyed that I just wasted three-and-a-half hours of my life and spent $1,945 to register and take the exam. Sometime...
Interesting Papers in Psychiatry - August 2025
Keeping up with the latest papers in the dozen or so big psychiatry journals is pretty difficult for me, because I don’t always have a reason to go through them. So, what if I gave myself a reason by being a Very Original Substacker and try...
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Authors
The writers behind this newsletter.
Psychiatrist, independently minded to a troublesome degree. Occasionally produces original thoughts worth sharing.
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