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Polypharmacy

Nils Wendel, MD, Kevin Kennedy, MD
Tens of paid subscribers

Rationalist-adjacent musings on psychiatry

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PricingOnly free issuesPublishesWeekly
Issues43Founded3 years agoLast Issue4 days ago
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Latest Issues

Is There Any Merit to Antipsychotic Polypharmacy?

Work in psychiatry for ~~long enough~~ any amount of time, really, and you will see patients with schizophrenia on some pretty heavy antipsychotic regimens. Here are a few recent med lists that I’ve seen:

Patient A:

  • Lurasidone 160mg...
4 days ago
15
8

Psychiatrists should not be superstitious pigeons

Photo via Psychology Pictures (from an experiment in which Skinner taught pigeons to play ping pong)

In 1948, the behavioralist B.F. Skinner published “‘Superstition’ in the Pigeon.”1 Skinner devised a contraption where he took starving pi...

12 days ago
35
16

Are we treating bipolar II disorder incorrectly?

I’ve been preparing lectures on the treatment and bipolar disorder, but I keep running into the same question: what is the point of bipolar II disorder?

I’m not arguing about the validity of the diagnosis, whether it’s underdiagnosed or ov...

a month ago
60
27

Seems Like Psychiatrists Should Probably Know About Modern Personality Theory: Part 2

Welcome to Part 2 in a series about the history of modern personality theory, with an emphasis on the Five Factor Model. In Part 1 we discussed:

  1. The idea of traits as components of an individual’s personality, which as a whole tells...
a month ago
21
9

The FDA's approval of Auvelity for agitation in dementia: An appraisal

In April, the FDA approved Auvelity (dextromethorphan-bupropion) for agitation in Alzheimer’s dementia (ADA). In a press release, then-Commissioner Makary stated that this “approval represents a significant advancement in our ability to hel...

2 months ago
18
9

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Authors

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  • Nils Wendel, MD

    Psychiatrist, independently minded to a troublesome degree. Occasionally produces original thoughts worth sharing.

  • Kevin Kennedy, MD

    An academic psychiatrist trying to improve the quality of evidence in psychiatry. I’m pro humility and against hype and bad science. All views my own. “A cynic is a man who knows the price of everything, and the value of nothing.”

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