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Artwork for Polypharmacy

Polypharmacy

Nils Wendel, MD

Rationalist-adjacent musings on things we do in psychiatry

Platform
Substack
PricingOnly free issuesPublishesWeekly
Issues30SubscribersRead polypharmacy.substack.com

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Latest Issues

Recent posts by this newsletter. Browse the email archive.

Why Are Psychiatry Boards So Useless?

Today I took my psychiatry boards. 425 multiple choice questions. I should feel glad to be done, but what I mostly feel is annoyed that I just wasted three-and-a-half hours of my life and spent $1,945 to register and take the exam. Sometime...

3 months ago
39
13

Interesting Papers in Psychiatry - August 2025

Keeping up with the latest papers in the dozen or so big psychiatry journals is pretty difficult for me, because I don’t always have a reason to go through them. So, what if I gave myself a reason by being a Very Original Substacker and try...

3 months ago
23
9

Notes To My Residents #3: How To Write Useful Notes

Notes To My Residents is a series of essays about my decision making in psychiatry, geared towards explaining to my current and future residents what I’m thinking, why I think that way, and how I come to make particular decisions.

4 months ago
28
9

Cobenfy Might Not Be A Good Adjunct

Back in April, BMS put out a press-release with data from their Phase 3 ARISE trial, saying that it failed to meet its primary endpoint. In short, using xanomeline/trospium (Cobenfy) as an adjunctive to the second-generation antidopaminergi...

4 months ago
13
6

Authors

The writers behind this newsletter.

  • Nils Wendel, MD

    Psychiatrist, independently minded to a troublesome degree. Occasionally produces original thoughts worth sharing.

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