A review of clinical trials in cardiovascular medicine that have had a major impact on the field. The trials are indexed according to major subject headings and presented in chronological order of publication date.
| Platform |  | Pricing | Freemium | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 204 | Founded | 3 years ago | Last Issue | 4 days ago |
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cardiologytrials.substack.comLatest Issues
Review of the APAF-CRT trials
Morbidity trial: Eur Heart J 2018;39:3999–4008
Mortality trial: Eur Heart J 2021;42:4731–4739
Background: APAF-CRT was conceived as a single research program executed in two consecutive, overlapping phases rather than as two independent...
Review of the AATAC trial
Circulation 2016;133:1637-1644
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist, and the prevalence of AF rises with worsening NYHA class, from roughly 5% in class I to approximately 50% in class IV. Prior ra...
Review of the MANTRA-PAF trial
N Engl J Med 2012;367:1587–1595
Background: The established paradigm for rhythm control in paroxysmal atrial fibrillation (AF) placed antiarrhythmic drug therapy as first-line treatment, with catheter ablation reserved for patients who fai...
Review of the ThermoCool AF trial
JAMA 2010;303(4):333–340
Background: By the mid-2000s, antiarrhythmic drug therapy had established itself as first-line rhythm control option for paroxysmal atrial fibrillation (AF), yet its limitations were well recognized - atrial fibril...
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A review of major clinical trials in cardiovascular medicine.
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