A review of clinical trials in cardiovascular medicine that have had a major impact on the field. The trials are indexed according to major subject headings and presented in chronological order of publication date.
| Platform |  | Pricing | Freemium | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 183 | Founded | 2 years ago | Last Issue | 3 days ago |
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cardiologytrials.substack.comLatest Issues
Review of the RACE Trial
N Engl J Med 2002;347:1834-1840
Background: By the late 1990s, the management of persistent atrial fibrillation rested on a clinical preference for restoring sinus rhythm. Repeated electrical cardioversion combined with prophylactic antiar...
Review of the AFFIRM Trial
N Engl J Med 2002;347:1825-33
Background: Atrial fibrillation is the most common sustained cardiac arrhythmia and was, at the time of AFFIRM, managed with two competing philosophies. The dominant approach was rhythm control: cardioversion...
Summaries and Indexes
This page is designed to help our readers navigate the trials efficiently. Each link below takes you directly to our summary of that section. To make navigation easier, every summary begins with a free index organized by intervention, so yo...
Review of the AVANT GUARD Trial
N Engl J Med 2026. DOI: 10.1056/NEJMoa2600929
Background: Atrial fibrillation is the most common sustained cardiac arrhythmia affecting more than 50 million people worldwide. Persistent atrial fibrillation (AF), defined as continuous AF la...
Review of the Ez-PAVE Trial
N Engl J Med 2026;394:1365-1375
Background: Lowering LDL cholesterol reduces cardiovascular risk, this is one of the most consistently reproduced findings in all of medicine. The evidence base that established this principle, however, was...
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A review of major clinical trials in cardiovascular medicine.
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