A review of clinical trials in cardiovascular medicine that have had a major impact on the field. The trials are indexed according to major subject headings and presented in chronological order of publication date.
| Platform |  | Pricing | Freemium | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 207 | Founded | 3 years ago | Last Issue | 7 days ago |
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cardiologytrials.substack.comLatest Issues
Review of the EARLY-AF trial
N Engl J Med. 2021;384(4):305-315.
Background: At the time of this trial, the recommended initial rhythm control strategy for symptomatic atrial fibrillation (AF) was anti-arrhythmic drugs with catheter ablation reserved for patients in wh...
Review of the CABANA trial
JAMA. 2019;321(13):1261-1274.
Background: Prior trials showed that patients who undergo ablation are more likely, compared to anti-arrhythmic drugs, to be in is sinus rhythm over long follow up. Whether restoring sinus rhythm through ablat...
Review of the CASTLE-AF trial
N Engl J Med 2018;378:417–427
Background: Prior trials such as AF-CHF and DIAMOND-CHF showed that drug rhythm control does not reduce mortality in patient with atrial fibrillation and heart failure. By the time CASTLE-AF was conceived, the...
Review of the APAF-CRT trials
Morbidity trial: Eur Heart J 2018;39:3999–4008
Mortality trial: Eur Heart J 2021;42:4731–4739
Background: APAF-CRT was conceived as a single research program executed in two consecutive, overlapping phases rather than as two independent...
Review of the AATAC trial
Circulation 2016;133:1637-1644
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist, and the prevalence of AF rises with worsening NYHA class, from roughly 5% in class I to approximately 50% in class IV. Prior ra...
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A review of major clinical trials in cardiovascular medicine.
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