Reletter
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The AI Engineer newsletter + Top technical AI podcast. How leading labs build Agents, Models, Infra, & AI for Science. See https://latent.space/about for highlights from Greg Brockman, Andrej Karpathy, George Hotz, Simon Willison, Soumith Chintala et al!

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Substack
PricingFreemiumPublishesDaily
Issues282Founded4 years agoLast Issue14 days ago
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Latest Issues

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI

Some people are going crazy over GPT 5.5. Some people. This is the story of the Jagged Frontier. People who use AI to write emails or even code implementation work find the lift moderate whereas people pushing the limits of the model are fi...

14 days ago
25
4

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

From building Applied Intuition from YC-era autonomy tooling into a $15B physical AI company, Qasar Younis and Peter Ludwig have spent the last decade living through the full arc of autonomy: from simulation and data infrastructure for robo...

22 days ago
19
1

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

Today, we check in a year after the first Unsupervised Learning x Latent Space Crossover special to discuss everything that has changed (there is a lot) in the world of AI. This episode was recorded just after AIE Europe, but before the Cur...

a month ago
21
1

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

Early bird discounts for the San Francisco World’s Fair, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock in ASAP!


From near-universal AI tool adoption inside Shopify to interna...

a month ago
25
1

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

Today, we explain this piece of “clickbait” from our guest!

true, but not how you think!

TL;DR: 95% of cancer treatments fail to pass clinical trials, but it may be a matching problem — if we better understood what patients have which tum...

a month ago
24

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Authors

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  • Latent.Space

    Writer, curator, latent space explorer. Main blog: https://swyx.io Devrel/Dev community: https://dx.tips/ Twitter: https://twitter.com/swyx

  • Nathan Lambert

    ML researcher making sense of AI research, products, and the uncertain technological future. PhD from Berkeley AI. Experience at Meta, DeepMind, HuggingFace.

  • RJ Honicky

    Data, ML, AI, Management, African and Latin music, languages, martial arts

  • Brandon Anderson

    Co-host of AI Science podcast as part of Latent.Space

  • Ankit Jain

    Founder of Aviator - multiplayer AI coding platform

  • Sebastian Raschka, PhD

    I'm an LLM research engineer 10+ years of experience in artificial intelligence. My expertise lies in AI & LLM research focusing on code-driven implementations. I am also the author of "Build a Large Language Model From Scratch" (amzn.to/4fqvn0D).

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