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Latest Issues

Is GLP-1-Related Muscle Loss Something to Worry About?

What the clinical trials actually say about semaglutide, tirzepatide, and lean mass—and why the headlines miss the bigger picture.

Yes—but probably less than many headlines suggest.

Concerns about muscle loss during treatment with GLP-1-b...

2 days ago
12
5

Women’s Health: The Preventive Medicine Gap We Can No Longer Ignore

Why healthcare must move beyond reproductive care to sex-specific cardiovascular risks, perimenopause, and evidence-based longevity.

Preventive medicine has transformed health through vaccination, screening, early diagnosis and interventio...

6 days ago
22
9

Fibromyalgia: From “Unexplained” Pain to a Biological Brain–Body Disorder

Fibromyalgia was once too easily described as pain without a cause. That position is becoming increasingly difficult to defend.

A growing body of genetics, neuroscience and physiology suggests that fibromyalgia is a genuine biological diso...

9 days ago
18
5

Long Covid and POTS: Are We Getting Closer to the Mechanism?

Orthostatic intolerance is one of the most common and disabling features of Long Covid, and a substantial subset of patients meet criteria for postural orthostatic tachycardia syndrome (POTS). The key question is no longer whether POTS occu...

13 days ago
15
6

POTS: What Is New in Treatment?

POTS is no longer short of treatments. It is short of certainty. The evidence is growing, but the studies remain small, the condition heterogeneous, and there is still no clearly established first-line drug.

Thanks for reading Mike’s Subst...

14 days ago
7
3

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Authors

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  • Dr Mike Hunter

    I am a retired gastroenterologist with a keen interest in the microbiome, immunity, and mitochondria. I write blog articles about gut health, wellness, exercise, nutrition, mental well-being, and photobiomodulation.

  • Kat Fu, M.S., M.S.

    20 yrs in health optimization, 15 in sleep | I solve sleep issues beyond hygiene & supplements | Get early access to my science-backed sleep intelligence app for men 40+ who care about brain health & longevity. iOS/Android. Waitlist \ud83d\udc47

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