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Paired Ends

Stephen Turner

Bioinformatics, computational biology, and data science updates from the field. Occasional posts on programming.

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Substack
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PublishesTwice weeklyIssues66
SubscribersRead blog.stephenturner.us

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Latest Issues

Recent posts by this newsletter. Browse the email archive.

Weekly Recap (March 2025, part 2)

This week’s recap highlights ESCARGOT, an AI agent for biomedical knowledge graphs and reasoning, CASTER for direct species tree inference from whole-genome alignments, the scGPT-spatial foundation model for spatial transcriptomics, the Bio...

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uv, part 2: building and publishing packages

This is part 2 of a series on uv. Other posts in this series:

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Weekly Recap (March 2025, part 1)

Here we are most of the way through March and I’m just getting around to my first “weekly” recap. It’s been a busy month — I’m writing a few papers of my own which I’ll share here when they’re published, and I took some much needed R&R in P...

a month ago
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GUIs for Local LLMs with RAG

Anyone reading this newsletter has surely used the frontier models like ChatGPT, Claude, and Gemini. I’ve written a few posts about using local models but haven’t really talked much about the tools I use to directly interact with these mode...

a month ago
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Authors

The writers behind this newsletter.

  • Stephen Turner

    Bioinformatician, computational biologist, data scientist

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