The Diagnostic Detective
The Diagnostic Detective introduces the world of medical tests to people without formal medical training. From the basics, to evaluating the latest medical technology, to advice on talking to your doctor about a test
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 65 | Founded | 3 years ago | Last Issue | 9 days ago |
| Active | |||||
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thediagnosticdetective.substack.comLatest Issues
We need to talk about calibration
Diagnostic studies of tests with continuous or ordinal outcomes love receiver operating characteristic curves. An ROC curve shows the sensitivity and false-positive rate at every possible threshold with the Area Under the ROC (AUROC or c-st...
When“Positive”and“Negative”Aren’t Enough
In my last post about communicating test accuracy to patients, I made a poor choice of example. Trying to avoid more discussion of tuberculosis (TB) tests, I chose a test for dementia with ordinal results (0–50) and rather glossed over the...
How should we communicate test accuracy to patients?
When I want to know what the evidence says about a medical question, the first place I usually look is the Cochrane Library. Cochrane reviews bring together all the relevant studies they can identify, assess their quality and use transparen...
Leaf plots meet decision thresholds
A few years ago, I came across a paper introducing something called a leaf plot. It struck me as one of those ideas that makes you wonder why everyone isn’t using it. Leaf plots, introduced by Malcolm and Tom Coulthard, provide a remarkably...
How I Would Have Presented the Pluslife TB Paper
I recently wrote about the missing evaluation in an NEJM paper evaluating the Pluslife MiniDock MTB test for tuberculosis. As a follow-up, I’d like to re-present the paper in the way I would have liked to see it in the first place. The back...
Audience Metrics
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| Subscribers | Engagement | 69 | Monthly Web Visits | ||
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| Accepts Sponsors | Estimated Cost per Ad | ||||
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Authors
The writers behind this newsletter.
Tom Boyles is an Infectious diseases clinician, author of the book 'How to Request a Test'. He is fascinated by the science (and anti-science) of medical tests
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