The Diagnostic Detective
The Diagnostic Detective introduces the world of medical tests to people without formal medical training. From the basics, to evaluating the latest medical technology, to advice on talking to your doctor about a test
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 67 | Founded | 3 years ago | Last Issue | 19 days ago |
| Active | |||||
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thediagnosticdetective.substack.comLatest Issues
When should we act without RCT level evidence?
Every week, the table of contents of the major medical journals includes another large randomised controlled trial (RCT) showing that a plausible intervention doesn’t work. Behind every one lies a convincing biological mechanism, supportive...
Imagine There Are No Statins. It’s Easy if You Try.
Articles about statins, or other lipid lowering therapies, can provoke almost as much controversy as articles about diets, so let me declare the rules of this thought experiment at the outset. I am not questioning the value of statins in se...
We need to talk about calibration
Diagnostic studies of tests with continuous or ordinal outcomes love receiver operating characteristic curves. An ROC curve shows the sensitivity and false-positive rate at every possible threshold with the Area Under the ROC (AUROC or c-st...
When“Positive”and“Negative”Aren’t Enough
In my last post about communicating test accuracy to patients, I made a poor choice of example. Trying to avoid more discussion of tuberculosis (TB) tests, I chose a test for dementia with ordinal results (0–50) and rather glossed over the...
How should we communicate test accuracy to patients?
When I want to know what the evidence says about a medical question, the first place I usually look is the Cochrane Library. Cochrane reviews bring together all the relevant studies they can identify, assess their quality and use transparen...
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| Subscribers | Engagement | 71 | Monthly Web Visits | ||
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| Accepts Sponsors | Estimated Cost per Ad | ||||
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Authors
The writers behind this newsletter.
Tom Boyles is an Infectious diseases clinician, author of the book 'How to Request a Test'. He is fascinated by the science (and anti-science) of medical tests
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