Better Microbiome Thinking
William DePaolo PhDUnderstand your microbiome, avoid the hype, and make smarter health decisions with evidence you can actually use.
| Platform |  | Pricing | Freemium | Publishes | Daily |
|---|---|---|---|---|---|
| Issues | 111 | Founded | a year ago | Last Issue | 6 days ago |
| Active | |||||
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williamdepaolo.substack.comLatest Issues
A Smarter Way to Choose a Probiotic
I’ve spent years watching probiotics get discussed in one of two ways: either as miracle products or as something too messy to make sense of.
Neither is useful.
That’s why I created the Probiotic Decision Kit.
It’s an 80+ page, science g...
“Which Probiotic Should I Take?” Is the Wrong First Question
The probiotic aisle offers abundance while the client conversation often lacks a decision process. A better recommendation begins with a defined goal and ends with a clear reassessment. The bottle enters the conversation only after those pi...
The UK Just Opened the Door to Microbiome Medicines. It Still Needs to Build the Path.
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The Medicines and Healthcare products Regulatory Agency has published a new position paper explaining how microbiome based medicinal products can be developed and authorized in the UK.
That sounds procedural. It is actually...
Your Microbiome Test Does Not Know What Your Gut Bacteria Are Doing
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Microbiome tests can find bacteria. Personalized diet reports often ask those results to predict an entire biological chain the assay never measured.
In February 2026, researchers from the National Institute of Standards and...
The Complete Guide to Interpreting Your Microbiome Test Results
Definitive guide | July 2026
A microbiome report can look more precise than the science beneath it.
You send a stool sample to a laboratory. A few weeks later, a polished dashboard appears. It assigns you a diversity score. It ranks your...
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| Subscribers | Engagement | 73 | Monthly Web Visits | ||
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| Accepts Sponsors | Estimated Cost per Ad | ||||
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Authors
The writers behind this newsletter.
Essays by William DePaolo, PhD on how the gut, brain, and environment shape one another. Exploring microbiome science beyond “good vs. bad bacteria” toward systems thinking, integration, and human meaning.
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