Understand your microbiome, avoid the hype, and make smarter health decisions with evidence you can actually use.
| Platform |  | Pricing | Freemium | Publishes | Daily |
|---|---|---|---|---|---|
| Issues | 123 | Founded | a year ago | Last Issue | 8 days ago |
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williamdepaolo.substack.comLatest Issues
Your Gut Microbiome Test Says You’re Abnormal. Compared With Whom?
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A microbiome report tells you that a bacterial population is low. Another earns a favorable rating, and somewhere on the page your gut receives a score that looks reassuringly precise. Before changing breakfast or buying a su...
The Seven Questions That Expose a Weak Microbiome Report
A paid subscriber field guide for separating measurement from microbiome theater
A microbiome report can contain fifty pages of organisms, pathways, food scores, and supplement recommendations while answering one surprisingly difficult que...
A Bigger Guest List Doesn’t Guarantee a Better Party
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Imagine going to dinner with someone who introduces their microbiome before ordering. Their diversity is excellent, their fermented food intake is aggressive, and their bacteria apparently have a five year plan. By the time t...
What Does a Better Gut Actually Look Like?
The Microbiome Deep Dive for paid subscribers
You eat a wider variety of plants. You buy the yogurt, remember the supplement, and start paying attention to what happens after lunch. Eventually, a reasonable question arrives. How will you k...
When the Biology Doesn’t Quite Fit: Thoughts on the Russian Pneumonic Plague Investigation
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Early in my scientific career, I worked with Yersinia pestis, the bacterium responsible for plague. It is one of those organisms that commands immediate respect in a laboratory. Not because it is mysterious, but because decad...
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Authors
The writers behind this newsletter.
Essays by William DePaolo, PhD on how the gut, brain, and environment shape one another. Exploring microbiome science beyond “good vs. bad bacteria” toward systems thinking, integration, and human meaning.
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