Better Microbiome Thinking
William DePaolo PhDEssays by William DePaolo, PhD on how the gut, brain, and environment shape one another. Exploring microbiome science beyond “good vs. bad bacteria” toward systems thinking, integration, and human meaning.
| Platform |  | Pricing | Freemium | Publishes | Daily |
|---|---|---|---|---|---|
| Issues | 78 | Founded | 7 months ago | Last Issue | 8 days ago |
| Active | |||||
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williamdepaolo.substack.comLatest Issues
Plagues Then and Now
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What do the Black Death, smallpox, the 1918 flu, HIV, COVID, cholera, and the 2026 hantavirus cruise ship outbreak have in common?
They all reveal the same thing: plagues are never just about microbes. They expose the fault...
Paper Cuts Review of "Gut microbiome composition and function reflect socioeconomic deprivation"
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I like this paper’s question. I do. Social deprivation gets into the body. It shapes stress, diet, sleep, healthcare access, environmental exposures, medication use, and a long list of other things that matter biologically. T...
The MV Hondius Outbreak Is Exactly What We’ve Been Warning About
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The news coming out of the MV Hondius this week should alarm anyone who has spent time thinking seriously about how infectious disease moves through human populations. As of May 4th, seven cases, two laboratory confirmed and...
9 Questions to Ask Before You Buy a Microbiome Supplement
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00:00:00):
Welcome back to another Microbiome Reality Check.
I’m William DePaolo and today we are discussing nine questions to ask before believing a microbiome supplement claim.
Everybody wants the microbiome to be fixabl...
A Parkinson’s Microbiome Paper, Five Big Claims, and the Peer Review File Everyone Should Read
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A new Nature Medicine paper argues that gut microbiome signatures associated with Parkinson’s disease may be detectable before Parkinson’s is clinically diagnosed.
That is an important idea.
It is also exactly the kind of i...
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Essays by William DePaolo, PhD on how the gut, brain, and environment shape one another. Exploring microbiome science beyond “good vs. bad bacteria” toward systems thinking, integration, and human meaning.
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